Linked Life Data

12370058

Source:http://linkedlifedata.com/resource/pubmed/id/12370058

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2002-10-8
pubmed:abstractText
Chemokine receptors are membrane proteins that play an important role in inflammation and the cellular entry of human immunodeficiency virus type I (HIV-1). Understanding the structure-function relationship of chemokine receptor-ligand interactions and developing novel strategies to control these interactions have important implications for therapeutic intervention of human diseases such as HIV-1 infection. This article reviews the work carried out in our laboratory in molecular modeling and site-directed mutagenesis of chemokine receptor-ligand interactions and chemical synthesis of chemokine-derived peptide agonists and antagonists. These studies demonstrate a paradigm for exploring and controlling membrane protein-protein interactions.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1389-5575
pubmed:author
pubmed:issnType
Print
pubmed:volume
2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
373-83
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
Structure, function and modulation of chemokine receptors: members of the g-protein-coupled receptor superfamily.
pubmed:affiliation
Department of Biochemistry, School of Molecular and Cellular Biology, University of Illinois at Urbana-Champaign, 61801, USA. z-huang@life.uiuc.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Review, Research Support, Non-U.S. Gov't