Source:http://linkedlifedata.com/resource/pubmed/id/12368956
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rdf:type | |
lifeskim:mentions |
umls-concept:C0006560,
umls-concept:C0009566,
umls-concept:C0026565,
umls-concept:C0035648,
umls-concept:C0085862,
umls-concept:C0149615,
umls-concept:C0205164,
umls-concept:C0229671,
umls-concept:C0441889,
umls-concept:C0442805,
umls-concept:C1299583,
umls-concept:C1549571,
umls-concept:C1608386,
umls-concept:C2745955
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pubmed:issue |
7
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pubmed:dateCreated |
2002-10-7
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pubmed:abstractText |
We monitored levels of C-reactive protein (CRP) in 96 consecutive adult allogeneic BMT patients (age 15-50 years) transplanted in our unit. Major transplant-related complications (MTC) occurred in 32% of cases and included: hepatic veno-occlusive disease, pneumonitis, severe endothelial leakage syndrome and >II acute GVHD. Transplant-related mortality (TRM) before day 100 post-BMT was 13.5%. Variables included in a stepwise logistic regression model were: gender, age, disease category, donor type, T cell depletion, TBI, use of growth factors, bacteremia, mean CRP-levels >50 mg/l between days 0 and 5 (CRP day 0-5) and >100 mg/l between days 6 and 10 (CRP day 6-10) post-BMT. Only high CRP-levels (for MTC and TRM) (P < 0.001) and donor-type (for TRM) (P= 0.02) were independent risk factors. The estimated probability for MTC was 73% (CRP day 6-10 >100 mg/l) vs 17% (CRP day 6-10 <100 mg/l). Using the same cut-off levels, the probabilities for TRM were 36.5% vs 1% in the identical sibling donor situation and 88% vs 12.5% in other donor-type transplants. We conclude that the degree of systemic inflammation, as reflected by CRP-levels, during the first 5-10 days after BMT identifies patients at risk of MTC and TRM. Our data may be useful in selecting patients for clinical trials involving pre-emptive anti-inflammatory treatment.
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pubmed:commentsCorrections | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0268-3369
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
30
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
441-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12368956-Adolescent,
pubmed-meshheading:12368956-Adult,
pubmed-meshheading:12368956-Biological Markers,
pubmed-meshheading:12368956-Bone Marrow Transplantation,
pubmed-meshheading:12368956-C-Reactive Protein,
pubmed-meshheading:12368956-Female,
pubmed-meshheading:12368956-Hematologic Diseases,
pubmed-meshheading:12368956-Humans,
pubmed-meshheading:12368956-Incidence,
pubmed-meshheading:12368956-Inflammation,
pubmed-meshheading:12368956-Male,
pubmed-meshheading:12368956-Middle Aged,
pubmed-meshheading:12368956-Retrospective Studies,
pubmed-meshheading:12368956-Risk Factors,
pubmed-meshheading:12368956-Transplantation, Homologous
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pubmed:year |
2002
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pubmed:articleTitle |
An early increase in serum levels of C-reactive protein is an independent risk factor for the occurrence of major complications and 100-day transplant-related mortality after allogeneic bone marrow transplantation.
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pubmed:affiliation |
BMT Unit, Academisch Ziekenhuis-Vrije Universiteit Brussel, Brussels, Belgium.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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