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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2002-10-30
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pubmed:abstractText |
Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) plays a critical role in peripheral tolerance. However, regulatory pathways initiated by the interactions of CTLA-4 with B7 counterligands expressed on antigen-presenting cells are not completely understood. We show here that long-term survival of pancreatic islet allografts induced by the soluble fusion protein CTLA-4-immunoglobulin (CTLA-4-Ig) is contingent upon effective tryptophan catabolism in the host. In vitro, we show that CTLA-4-Ig regulates cytokine-dependent tryptophan catabolism in B7-expressing dendritic cells. These data suggest that modulation of tryptophan catabolism is a means by which CTLA-4 functions in vivo and that CTLA-4 acts as a ligand for B7 receptor molecules that transduce intracellular signals.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/4-(4-fluorophenyl)-2-(4-hydroxypheny...,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD80,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation,
http://linkedlifedata.com/resource/pubmed/chemical/CTLA-4 Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/Ctla4 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Imidazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoconjugates,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin G,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Isoantigens,
http://linkedlifedata.com/resource/pubmed/chemical/Kynurenine,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B,
http://linkedlifedata.com/resource/pubmed/chemical/Peptides,
http://linkedlifedata.com/resource/pubmed/chemical/Pyridines,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/SN50 peptide,
http://linkedlifedata.com/resource/pubmed/chemical/STAT1 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Stat1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/Tryptophan,
http://linkedlifedata.com/resource/pubmed/chemical/Tryptophan Oxygenase,
http://linkedlifedata.com/resource/pubmed/chemical/abatacept,
http://linkedlifedata.com/resource/pubmed/chemical/p38 Mitogen-Activated Protein...
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1529-2908
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pubmed:author |
pubmed-author:BelladonnaMaria LML,
pubmed-author:BianchiRobertaR,
pubmed-author:CalcinaroFilippoF,
pubmed-author:CandeloroPaolaP,
pubmed-author:FallarinoFrancescaF,
pubmed-author:FalorniAlbertoA,
pubmed-author:FiorettiMaria CMC,
pubmed-author:GrohmannUrsulaU,
pubmed-author:OrabonaCirianaC,
pubmed-author:PuccettiPaoloP,
pubmed-author:VaccaCarmineC
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pubmed:issnType |
Print
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pubmed:volume |
3
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1097-101
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:12368911-Animals,
pubmed-meshheading:12368911-Antigen Presentation,
pubmed-meshheading:12368911-Antigens, CD,
pubmed-meshheading:12368911-Antigens, CD80,
pubmed-meshheading:12368911-Antigens, Differentiation,
pubmed-meshheading:12368911-CTLA-4 Antigen,
pubmed-meshheading:12368911-Cells, Cultured,
pubmed-meshheading:12368911-DNA-Binding Proteins,
pubmed-meshheading:12368911-Dendritic Cells,
pubmed-meshheading:12368911-Diabetes Mellitus, Experimental,
pubmed-meshheading:12368911-Enzyme Activation,
pubmed-meshheading:12368911-Enzyme Inhibitors,
pubmed-meshheading:12368911-Gene Expression Regulation,
pubmed-meshheading:12368911-Graft Enhancement, Immunologic,
pubmed-meshheading:12368911-Graft Survival,
pubmed-meshheading:12368911-Imidazoles,
pubmed-meshheading:12368911-Immune Tolerance,
pubmed-meshheading:12368911-Immunoconjugates,
pubmed-meshheading:12368911-Immunoglobulin G,
pubmed-meshheading:12368911-Interferon-gamma,
pubmed-meshheading:12368911-Islets of Langerhans Transplantation,
pubmed-meshheading:12368911-Isoantigens,
pubmed-meshheading:12368911-Kynurenine,
pubmed-meshheading:12368911-MAP Kinase Signaling System,
pubmed-meshheading:12368911-Male,
pubmed-meshheading:12368911-Mice,
pubmed-meshheading:12368911-Mice, Inbred BALB C,
pubmed-meshheading:12368911-Mice, Inbred C57BL,
pubmed-meshheading:12368911-Mice, Knockout,
pubmed-meshheading:12368911-Mitogen-Activated Protein Kinases,
pubmed-meshheading:12368911-NF-kappa B,
pubmed-meshheading:12368911-Peptides,
pubmed-meshheading:12368911-Pyridines,
pubmed-meshheading:12368911-Recombinant Fusion Proteins,
pubmed-meshheading:12368911-STAT1 Transcription Factor,
pubmed-meshheading:12368911-Trans-Activators,
pubmed-meshheading:12368911-Transplantation, Homologous,
pubmed-meshheading:12368911-Tryptophan,
pubmed-meshheading:12368911-Tryptophan Oxygenase,
pubmed-meshheading:12368911-p38 Mitogen-Activated Protein Kinases
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pubmed:year |
2002
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