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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6906
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pubmed:dateCreated |
2002-10-7
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pubmed:abstractText |
Species of malaria parasite that infect rodents have long been used as models for malaria disease research. Here we report the whole-genome shotgun sequence of one species, Plasmodium yoelii yoelii, and comparative studies with the genome of the human malaria parasite Plasmodium falciparum clone 3D7. A synteny map of 2,212 P. y. yoelii contiguous DNA sequences (contigs) aligned to 14 P. falciparum chromosomes reveals marked conservation of gene synteny within the body of each chromosome. Of about 5,300 P. falciparum genes, more than 3,300 P. y. yoelii orthologues of predominantly metabolic function were identified. Over 800 copies of a variant antigen gene located in subtelomeric regions were found. This is the first genome sequence of a model eukaryotic parasite, and it provides insight into the use of such systems in the modelling of Plasmodium biology and disease.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0028-0836
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pubmed:author |
pubmed-author:AllenJonathan EJE,
pubmed-author:AngiuoliSamuel VSV,
pubmed-author:BergmanLawrence WLW,
pubmed-author:BidwellShelby LSL,
pubmed-author:CarltonJane MJM,
pubmed-author:CarucciDaniel JDJ,
pubmed-author:ChoJennifer KJK,
pubmed-author:CummingsLeda MLM,
pubmed-author:CunninghamDeirdre ADA,
pubmed-author:ErmolaevaMaria DMD,
pubmed-author:FeldblyumTamara VTV,
pubmed-author:FlorensLaurenceL,
pubmed-author:FraserClaire MCM,
pubmed-author:GardnerMalcolm JMJ,
pubmed-author:HarrisMichael AMA,
pubmed-author:HoffmanStephen LSL,
pubmed-author:JanseChris JCJ,
pubmed-author:KooHean LHL,
pubmed-author:KooijTaco WTW,
pubmed-author:KosackDaniel SDS,
pubmed-author:PerteaMihaelaM,
pubmed-author:PetersonJeremy DJD,
pubmed-author:PopMihaiM,
pubmed-author:PreiserPeter RPR,
pubmed-author:QuackenbushJohnJ,
pubmed-author:RaineJ DaleJD,
pubmed-author:RiedmullerSteven BSB,
pubmed-author:SalzbergSteven LSL,
pubmed-author:SedegahMarthaM,
pubmed-author:SelengutJeremy DJD,
pubmed-author:ShallomShamira JSJ,
pubmed-author:ShoaibiAzadehA,
pubmed-author:ShumwayMartin FMF,
pubmed-author:SilvaJoana CJC,
pubmed-author:SindenRobert ERE,
pubmed-author:SmithHamilton OHO,
pubmed-author:SuhBernard BBB,
pubmed-author:VaidyaAkhil BAB,
pubmed-author:VenterJ CraigJC,
pubmed-author:WatersAndrew PAP,
pubmed-author:WhiteOwen ROR,
pubmed-author:YatesJohn RJR,
pubmed-author:van AkenSusan ESE,
pubmed-author:van LinLeo HLH
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pubmed:issnType |
Print
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pubmed:day |
3
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pubmed:volume |
419
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
512-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12368865-Animals,
pubmed-meshheading:12368865-DNA, Protozoan,
pubmed-meshheading:12368865-Disease Models, Animal,
pubmed-meshheading:12368865-Genome, Protozoan,
pubmed-meshheading:12368865-Humans,
pubmed-meshheading:12368865-Malaria,
pubmed-meshheading:12368865-Multigene Family,
pubmed-meshheading:12368865-Plasmodium falciparum,
pubmed-meshheading:12368865-Plasmodium yoelii,
pubmed-meshheading:12368865-Recombination, Genetic,
pubmed-meshheading:12368865-Rodentia,
pubmed-meshheading:12368865-Sequence Alignment,
pubmed-meshheading:12368865-Sequence Analysis, DNA,
pubmed-meshheading:12368865-Species Specificity,
pubmed-meshheading:12368865-Synteny,
pubmed-meshheading:12368865-Telomere
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pubmed:year |
2002
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pubmed:articleTitle |
Genome sequence and comparative analysis of the model rodent malaria parasite Plasmodium yoelii yoelii.
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pubmed:affiliation |
The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, Maryland 20850, USA. carlton@tigr.org
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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