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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2002-10-2
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pubmed:abstractText |
Primary sclerosing cholangitis (PSC) predisposes individuals to cholangiocarcinoma; however, the molecular mechanisms involved in the carcinogenesis process remain unclear. Because p16(INK4a) inactivation has been implicated in cholangiocarcinoma, our aims were to examine PSC cholangiocytes for p16(INK4a) gene mutations.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0016-5085
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
123
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1090-8
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:12360471-Bile Duct Neoplasms,
pubmed-meshheading:12360471-Bile Ducts, Intrahepatic,
pubmed-meshheading:12360471-Cholangiocarcinoma,
pubmed-meshheading:12360471-Cholangitis, Sclerosing,
pubmed-meshheading:12360471-CpG Islands,
pubmed-meshheading:12360471-Cyclin-Dependent Kinase Inhibitor p16,
pubmed-meshheading:12360471-DNA Methylation,
pubmed-meshheading:12360471-Exons,
pubmed-meshheading:12360471-Gene Expression,
pubmed-meshheading:12360471-Genes, Reporter,
pubmed-meshheading:12360471-Genetic Predisposition to Disease,
pubmed-meshheading:12360471-Humans,
pubmed-meshheading:12360471-Luciferases,
pubmed-meshheading:12360471-Mutagenesis, Site-Directed,
pubmed-meshheading:12360471-Mutation,
pubmed-meshheading:12360471-Prevalence,
pubmed-meshheading:12360471-Promoter Regions, Genetic,
pubmed-meshheading:12360471-Transcriptional Activation
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pubmed:year |
2002
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pubmed:articleTitle |
p16INK4a promoter mutations are frequent in primary sclerosing cholangitis (PSC) and PSC-associated cholangiocarcinoma.
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pubmed:affiliation |
Division of Gastroenterology and Hepatology, Mayo Medical School, Clinic, and Foundation, Rochester, Minnesota 55905, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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