|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
19
|
|
pubmed:dateCreated |
2002-10-2
|
|
pubmed:abstractText |
Cyclooxygenase 2 (HER-2) (Cox-2), an inducible form of Cox, is overexpressed in HER-2/neu-positive human breast cancers. The aim of this study was to determine whether celecoxib, a selective Cox-2 inhibitor, protected against HER-2/neu-induced experimental breast cancer. Cox-2 protein was detected in breast carcinomas from mouse mammary tumor virus (MMTV)/neu mice. Treatment with celecoxib (500 ppm) significantly reduced the incidence of mammary tumors in MMTV/neu mice (P = 0.003) and caused about a 50% reduction in mammary prostaglandin E2 (PGE2) levels. Because mammary glands from MMTV/neu mice expressed all four PGE2 receptor subtypes, we speculate that signaling through PGE2 receptors is important for mammary tumorigenesis. These results strengthen the rationale for developing clinical trials to determine whether selective Cox-2 inhibitors possess anticancer properties in humans at risk for breast cancer.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anticarcinogenic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 2,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 2 Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Isoenzymes,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/PTGS2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Prostaglandin-Endoperoxide Synthases,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, erbB-2,
http://linkedlifedata.com/resource/pubmed/chemical/Sulfonamides,
http://linkedlifedata.com/resource/pubmed/chemical/celecoxib
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Oct
|
|
pubmed:issn |
0008-5472
|
|
pubmed:author |
pubmed-author:BrownAnthony M CAM,
pubmed-author:DannenbergAndrew JAJ,
pubmed-author:DeoraAparnaA,
pubmed-author:DuBaohengB,
pubmed-author:HoweLouise RLR,
pubmed-author:HudisCliffordC,
pubmed-author:MasferrerJaime LJL,
pubmed-author:MullerWilliam JWJ,
pubmed-author:ParksS NSN,
pubmed-author:SubbaramaiahKothaK,
pubmed-author:ThalerHoward THT
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
1
|
|
pubmed:volume |
62
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
5405-7
|
|
pubmed:dateRevised |
2009-11-19
|
|
pubmed:meshHeading |
pubmed-meshheading:12359744-Animals,
pubmed-meshheading:12359744-Anticarcinogenic Agents,
pubmed-meshheading:12359744-Cyclooxygenase 2,
pubmed-meshheading:12359744-Cyclooxygenase 2 Inhibitors,
pubmed-meshheading:12359744-Cyclooxygenase Inhibitors,
pubmed-meshheading:12359744-Female,
pubmed-meshheading:12359744-Humans,
pubmed-meshheading:12359744-Isoenzymes,
pubmed-meshheading:12359744-Mammary Neoplasms, Experimental,
pubmed-meshheading:12359744-Mammary Tumor Virus, Mouse,
pubmed-meshheading:12359744-Membrane Proteins,
pubmed-meshheading:12359744-Mice,
pubmed-meshheading:12359744-Mice, Transgenic,
pubmed-meshheading:12359744-Prostaglandin-Endoperoxide Synthases,
pubmed-meshheading:12359744-Pyrazoles,
pubmed-meshheading:12359744-Receptor, erbB-2,
pubmed-meshheading:12359744-Sulfonamides
|
|
pubmed:year |
2002
|
|
pubmed:articleTitle |
Celecoxib, a selective cyclooxygenase 2 inhibitor, protects against human epidermal growth factor receptor 2 (HER-2)/neu-induced breast cancer.
|
|
pubmed:affiliation |
Department of Cell and Developmental Biology, Weill Medical College of Cornell University, New York, New York 10021, USA. lrhowe@med.cornell.edu
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
