Source:http://linkedlifedata.com/resource/pubmed/id/12357368
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
10
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| pubmed:dateCreated |
2002-10-1
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| pubmed:abstractText |
We studied eight patients with characteristic features of angio-immunoblastic T cell lymphoma (AILD-TL) associated with more than 25% of large B cells. Polymerase chain reaction (PCR) analysis showed a clonal rearrangement of the T cell receptor (TCR)-gamma chain gene in all cases. One additional case showed a clonal rearrangement of the TCR-beta chain gene by Southern blot hybridization. PCR analysis showed a clonal immunoglobulin rearrangement in three cases presenting with more than 50% of large B cells whereas the other cases had a germline configuration. In 6/8 cases, double-labeling immunohistochemistry and in situ hybridization demonstrated that Epstein-Barr virus (EBV) was mostly present in the large B cells but also detected in some T cells. We further evaluated the frequency of AILD-TL with more than 25% of large B cells in the 106 cases collected by the French GELA group and found an incidence of 18%. The outcome of these patients did not differ significantly from those with less than 25% of B cells. With this approach we confirm the heterogeneity of AILD-TL features and the possible association with a substantial numbers of CD20(+), EBV(+) large B cells. We propose to denominate these cases as 'AILD-TL rich in large B cells' and to consider them as a different entity which can be misdiagnosed as a reactive process or as T cell rich B cell lymphoma.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
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| pubmed:issn |
0887-6924
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| pubmed:author |
pubmed-author:BrousseNN,
pubmed-author:CanioniDD,
pubmed-author:DamotteDD,
pubmed-author:DelabesseEE,
pubmed-author:French Groupe d'Etude des Lymphomes de l'Adulte (GELA),
pubmed-author:GaulardPP,
pubmed-author:HermineOO,
pubmed-author:Lome-MaldonadoCC,
pubmed-author:MacintyreEE,
pubmed-author:RaffouxEE
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| pubmed:issnType |
Print
|
| pubmed:volume |
16
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
2134-41
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| pubmed:dateRevised |
2004-11-17
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| pubmed:meshHeading |
pubmed-meshheading:12357368-Aged,
pubmed-meshheading:12357368-Aged, 80 and over,
pubmed-meshheading:12357368-B-Lymphocytes,
pubmed-meshheading:12357368-Blotting, Southern,
pubmed-meshheading:12357368-Epstein-Barr Virus Infections,
pubmed-meshheading:12357368-Female,
pubmed-meshheading:12357368-Gene Rearrangement, T-Lymphocyte,
pubmed-meshheading:12357368-Humans,
pubmed-meshheading:12357368-Immunohistochemistry,
pubmed-meshheading:12357368-Lymphoma, Large-Cell, Immunoblastic,
pubmed-meshheading:12357368-Male,
pubmed-meshheading:12357368-Middle Aged,
pubmed-meshheading:12357368-Polymerase Chain Reaction,
pubmed-meshheading:12357368-Receptors, Antigen, T-Cell, gamma-delta
|
| pubmed:year |
2002
|
| pubmed:articleTitle |
Angio-immunoblastic T cell lymphoma (AILD-TL) rich in large B cells and associated with Epstein-Barr virus infection. A different subtype of AILD-TL?
|
| pubmed:affiliation |
Department of Pathology (EA 219, University Paris V), Hôpital Necker-Enfants Malades, France.
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| pubmed:publicationType |
Journal Article
|