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pubmed-article:12356640pubmed:abstractTextTissue-type plasminogen activator (tPA) and urokinase-type plasminogen activator (uPA) are thought to play critical roles in vascular remodeling after injury, with tPA mediating intravascular clot lysis and uPA modulating cell migration within the vessel wall. In human vascular disease, however, thrombus organization and neointimal formation are closely interrelated processes. This study examines the differential roles of tPA and uPA in these processes in mice.lld:pubmed
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pubmed-article:12356640pubmed:articleTitleDifferent mechanisms of increased luminal stenosis after arterial injury in mice deficient for urokinase- or tissue-type plasminogen activator.lld:pubmed
pubmed-article:12356640pubmed:affiliationGeorg August University, Department of Cardiology and Pulmonary Medicine, Goettingen, Germany.lld:pubmed
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pubmed-article:12356640pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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