Linked Life Data

12355958

Source:http://linkedlifedata.com/resource/pubmed/id/12355958

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
2002-10-1
pubmed:abstractText
Common genetic variations may, in large part, explain genetic predispositions to common diseases and individual differences in pharmacological responsiveness. Single-nucleotide polymorphisms (SNPs) are the most frequent type of genetic variation, and are thought to be present every several-hundred bases, on average, throughout the human genome. SNPs can provide medically important information through (1) their contribution to high-density maps for studies of susceptibility to common diseases; (2) provision of genetic data for personalized medical service; and (3) identification of genes associated with the efficacy and side-effect of drugs. We have been focusing on genomic loci that encode various enzymes and transporters involved in the metabolism of drugs, and have described more than 5,500 SNP and other variations. Our collection of human variations should prove useful for investigations designed to detect associations between genetic variations and common diseases or responsiveness to drug therapy. In this review we introduce the recent progress and future direction of human genome analysis and its impact on medicine.
pubmed:language
jpn
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0385-0684
pubmed:author
pubmed:issnType
Print
pubmed:volume
29
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1665-73
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
[SNP collection, pharmacogenomics, and the future of drug therapy].
pubmed:affiliation
Laboratory for Genotyping, RIKEN SNP Research Center.
pubmed:publicationType
Journal Article, English Abstract, Review