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rdf:type |
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lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0021756,
umls-concept:C0039194,
umls-concept:C0083032,
umls-concept:C0185117,
umls-concept:C0337112,
umls-concept:C0851285,
umls-concept:C1524075,
umls-concept:C1879547,
umls-concept:C2003941,
umls-concept:C2911684
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pubmed:issue |
21
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pubmed:dateCreated |
2002-10-16
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pubmed:abstractText |
Interleukin (IL)-2 is a type I four-alpha-helical bundle cytokine that plays vital roles in antigen-mediated proliferation of peripheral blood T cells and also is critical for activation-induced cell death. We now demonstrate that IL-2 potently decreases expression of IL-7 receptor alpha chain (IL-7Ralpha) mRNA and protein. The fact that IL-7Ralpha is a component of the receptors for both IL-7 and thymic stromal lymphopoietin (TSLP) suggests that IL-2 can negatively regulate signals by each of these cytokines. Previously it was known that the IL-2 and IL-7 receptors shared the common cytokine receptor gamma chain, gamma(c), which suggested a possible competition between these cytokines for a receptor component. Our findings now suggest a previously unknown type of cross-talk between IL-2 and IL-7 signaling by showing that IL-2 signaling can diminish IL-7Ralpha expression via a phosphatidylinositol 3-kinase/Akt-dependent mechanism.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/12354940-10072077,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12354940-10379911,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12354940-10404594,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12354940-10514006,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12354940-10754284,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12354940-10784451,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12354940-10851055,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12354940-10881176,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12354940-10974032,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12354940-11062503,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12354940-11447288,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12354940-11485747,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12354940-11905829,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12354940-7515100,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12354940-7584142,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12354940-7699333,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12354940-7716517,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12354940-7719938,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12354940-7737351,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12354940-7770771,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12354940-7964471,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12354940-8106507,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12354940-8112430,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12354940-8257416,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12354940-8397196,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12354940-8402910,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12354940-8557675,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12354940-8643566,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12354940-8700888,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12354940-8816482,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12354940-9162082,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12354940-9215624,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12354940-9215626,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12354940-9469423,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12354940-9505189,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12354940-9768361,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12354940-9774657,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12354940-9808174,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12354940-9843216,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12354940-9916685,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12354940-9916699
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/AKT1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-2,
http://linkedlifedata.com/resource/pubmed/chemical/Milk Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphatidylinositol 3-Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-akt,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interleukin-7,
http://linkedlifedata.com/resource/pubmed/chemical/STAT5 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/interleukin-7 receptor, alpha chain
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
99
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
13759-64
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:12354940-Humans,
pubmed-meshheading:12354940-Animals,
pubmed-meshheading:12354940-Mice,
pubmed-meshheading:12354940-Milk Proteins,
pubmed-meshheading:12354940-RNA, Messenger,
pubmed-meshheading:12354940-Lymphocyte Activation,
pubmed-meshheading:12354940-Mice, Inbred C57BL,
pubmed-meshheading:12354940-T-Lymphocytes,
pubmed-meshheading:12354940-Gene Expression Regulation,
pubmed-meshheading:12354940-Signal Transduction,
pubmed-meshheading:12354940-DNA-Binding Proteins
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