Source:http://linkedlifedata.com/resource/pubmed/id/12322986
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
23
|
| pubmed:dateCreated |
2002-9-26
|
| pubmed:abstractText |
We recently, developed a simple one-day one-step incubation method to obtain bone-like apatite coating on flexible and biodegradable Polyactive 1000PEGT70PBT30. The present study reports a preliminary biological evaluation on the coated polymer after implantation in rabbit femurs. The porous cylindrical implants were produced from a block fabricated by injection molding and salt leaching. This technique provided the block necessary mechanical integrity to make small cylinders (diameter 3.5 x 5 mm2) that were suitable for implantation in rabbits. The coating continuously covered the surface of the polymer, preserving the porous architecture of outer contour of the cylinders. Two defects with a diameter of 3.5 or 4 mm were drilled in the proximal and distal part of femur diaphysis. The implants were inserted as press-fit or undersized into the cortex as well as in the marrow cavity. The polymer swelled after implantation due to hydration, leading to a tight contact with the surrounding bone in both defects. The adherence of the coating on the polymer proved to be sufficient to endure a steam sterilization process as well as the 15% swelling of the polymer in vivo. The coated Polyactive 1000PEGT70PBT30 has a good osteoconductive property, as manifested by abundant bone growth into marrow cavity along the implant surface during 4-week implantation. A favorable bioactive effect of the coating with an intimate bone contact and extensive bone bonding with this polymer was qualitatively confirmed. Concerning the bone ingrowth into the porous implant in the defect of 4 mm diameter, only marginal bone formation was observed up to 8 weeks with a maximal penetration depth of about 1 mm. The pore interconnectivity is important not only for producing a coating inside the porous structure but also for bone ingrowth into this biodegradable material. This preliminary study provided promising evidence for a further study using a bigger animal model.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
0142-9612
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
23
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
4649-56
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:12322986-Animals,
pubmed-meshheading:12322986-Apatites,
pubmed-meshheading:12322986-Biocompatible Materials,
pubmed-meshheading:12322986-Biomechanics,
pubmed-meshheading:12322986-Biomimetics,
pubmed-meshheading:12322986-Bone Development,
pubmed-meshheading:12322986-Bone and Bones,
pubmed-meshheading:12322986-Female,
pubmed-meshheading:12322986-Hydrogen-Ion Concentration,
pubmed-meshheading:12322986-Materials Testing,
pubmed-meshheading:12322986-Microscopy, Electron, Scanning,
pubmed-meshheading:12322986-Osseointegration,
pubmed-meshheading:12322986-Polyesters,
pubmed-meshheading:12322986-Polyethylene Glycols,
pubmed-meshheading:12322986-Prostheses and Implants,
pubmed-meshheading:12322986-Rabbits,
pubmed-meshheading:12322986-Scattering, Radiation,
pubmed-meshheading:12322986-Time Factors
|
| pubmed:year |
2002
|
| pubmed:articleTitle |
Bone growth in biomimetic apatite coated porous Polyactive 1000PEGT70PBT30 implants.
|
| pubmed:affiliation |
IsoTis N V, Bilthoven, The Netherlands.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|