Linked Life Data

12296446

Source:http://linkedlifedata.com/resource/pubmed/id/12296446

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2002-9-25
pubmed:abstractText
The heparin and deoxycholic acid conjugate (heparin-DOCA) synthesized in this study has an amphiphilic property and could be completely dissolved in a co-solvent made of 1,4-dioxane (50 v/v%), n-propanol (25 v/v%), and water (25 v/v%). A polycaprolacton (PCL)-polyethylene glycol (PEG) multiblock copolymer was used as the coating matrix; this polymer also dissolved readily in the same co-solvent. Heparin-DOCA and the PCL-PEG multiblock copolymer were mixed well to produce a transparent coated film on an angio-catheter. The bioactivity of the released heparin-DOCA was determined by evaluating platelet adhesion and fibrin formation on the coated surfaces. The release rate could be controlled by the loading amount of the drug and drug release was maintained for 12 h. The released heparin-DOCA significantly prevented platelet adhesion and fibrin formation at the surfaces, as well as in the bulk in the plasma.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0920-5063
pubmed:author
pubmed:issnType
Print
pubmed:volume
13
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
817-28
pubmed:dateRevised
2008-2-20
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
Improved blood compatibility by sustained release of heparin-deoxycholic acid conjugates in a PCL-PEG multiblock copolymer matrix.
pubmed:affiliation
Department of Materials Science and Engineering, Kwangju Institute of Science and Technology, Gwangju, Korea.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't