Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2002-9-20
pubmed:abstractText
An allelic series of mutations is an extremely valuable genetic resource for understanding gene function. Here we describe eight mutant alleles at the Steel (Sl) locus of mice that were induced with N-ethyl-N-nitrosourea (ENU). The product of the Sl locus is Kit ligand (or Kitl; also known as mast cell growth factor, stem cell factor, and Steel factor), which is a member of the helical cytokine superfamily and is the ligand for the Kit receptor tyrosine kinase. Seven of the eight ENU-induced Kitl(Sl) alleles, of which five cause missense mutations, one causes a nonsense mutation and exon skipping, and one affects a splice site, were found to contain point mutations in Kitl. Interestingly, each of the five missense mutations affects residues that are within, or very near, conserved alpha-helical domains of Kitl. These ENU-induced mutants should provide important information on structural requirements for function of Kitl and other helical cytokines.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/12242244-10469849, http://linkedlifedata.com/resource/pubmed/commentcorrection/12242244-10880433, http://linkedlifedata.com/resource/pubmed/commentcorrection/12242244-10881197, http://linkedlifedata.com/resource/pubmed/commentcorrection/12242244-10884405, http://linkedlifedata.com/resource/pubmed/commentcorrection/12242244-10886009, http://linkedlifedata.com/resource/pubmed/commentcorrection/12242244-11152680, http://linkedlifedata.com/resource/pubmed/commentcorrection/12242244-1183807, http://linkedlifedata.com/resource/pubmed/commentcorrection/12242244-1378327, http://linkedlifedata.com/resource/pubmed/commentcorrection/12242244-1381905, http://linkedlifedata.com/resource/pubmed/commentcorrection/12242244-1383087, http://linkedlifedata.com/resource/pubmed/commentcorrection/12242244-1384484, http://linkedlifedata.com/resource/pubmed/commentcorrection/12242244-1455231, http://linkedlifedata.com/resource/pubmed/commentcorrection/12242244-14942747, http://linkedlifedata.com/resource/pubmed/commentcorrection/12242244-1684639, http://linkedlifedata.com/resource/pubmed/commentcorrection/12242244-1698558, http://linkedlifedata.com/resource/pubmed/commentcorrection/12242244-1705866, http://linkedlifedata.com/resource/pubmed/commentcorrection/12242244-1707344, http://linkedlifedata.com/resource/pubmed/commentcorrection/12242244-1708771, http://linkedlifedata.com/resource/pubmed/commentcorrection/12242244-1711207, http://linkedlifedata.com/resource/pubmed/commentcorrection/12242244-1717457, http://linkedlifedata.com/resource/pubmed/commentcorrection/12242244-2208279, http://linkedlifedata.com/resource/pubmed/commentcorrection/12242244-3194417, http://linkedlifedata.com/resource/pubmed/commentcorrection/12242244-3342938, http://linkedlifedata.com/resource/pubmed/commentcorrection/12242244-6954505, http://linkedlifedata.com/resource/pubmed/commentcorrection/12242244-7507105, http://linkedlifedata.com/resource/pubmed/commentcorrection/12242244-7514387, http://linkedlifedata.com/resource/pubmed/commentcorrection/12242244-7519481, http://linkedlifedata.com/resource/pubmed/commentcorrection/12242244-7530502, http://linkedlifedata.com/resource/pubmed/commentcorrection/12242244-7531500, http://linkedlifedata.com/resource/pubmed/commentcorrection/12242244-7533739, http://linkedlifedata.com/resource/pubmed/commentcorrection/12242244-7683280, http://linkedlifedata.com/resource/pubmed/commentcorrection/12242244-8049518, http://linkedlifedata.com/resource/pubmed/commentcorrection/12242244-8145851, http://linkedlifedata.com/resource/pubmed/commentcorrection/12242244-8430317, http://linkedlifedata.com/resource/pubmed/commentcorrection/12242244-8490655, http://linkedlifedata.com/resource/pubmed/commentcorrection/12242244-8849899, http://linkedlifedata.com/resource/pubmed/commentcorrection/12242244-8875893, http://linkedlifedata.com/resource/pubmed/commentcorrection/12242244-8939697, http://linkedlifedata.com/resource/pubmed/commentcorrection/12242244-8984348, http://linkedlifedata.com/resource/pubmed/commentcorrection/12242244-9045664, http://linkedlifedata.com/resource/pubmed/commentcorrection/12242244-9071596, http://linkedlifedata.com/resource/pubmed/commentcorrection/12242244-9360640, http://linkedlifedata.com/resource/pubmed/commentcorrection/12242244-9480777, http://linkedlifedata.com/resource/pubmed/commentcorrection/12242244-9565637, http://linkedlifedata.com/resource/pubmed/commentcorrection/12242244-9825669
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0016-6731
pubmed:author
pubmed:issnType
Print
pubmed:volume
162
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
331-40
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
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