Source:http://linkedlifedata.com/resource/pubmed/id/12238327
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
2002-9-19
|
| pubmed:abstractText |
We investigated whether radiation-induced pica, a behavior characterized by the eating of a non-food substance, such as kaolin, can be used as an index of radiation-induced vomiting in rats. Since there was an individual difference in the susceptibility to pica, we selected rats that actually ate kaolin following X-ray irradiation, and used them for the experiment. The total-body irradiation (TBI) increased kaolin consumption in a dose-dependent manner (sham, 0.05 +/- 0.03 (SEM) g; 2 Gy, 0.38 +/- 0.11 g; 4 Gy, 1.54 +/- 0.28 g; 8 Gy, 3.55 +/- 0.67 g), and the increased kaolin consumption after 4 Gy of TBI was inhibited by a pretreatment with the serotonin 5-HT3 receptor antagonist ondansetron (2 mg/kg, i.p.) (saline, 1.49 +/- 0.33 g; ondansetron, 0.75 +/- 0.11 g). Furthermore, 4 Gy of abdominal irradiation was more effective to induce pica than that of head irradiation (abdomen: 0.37 +/- 0.05 g, head: 0.06 +/- 0.01 g). These findings suggested that peripheral serotonergic pathway is predominantly involved in the development of radiation-induced pica in rats and that the radiation-induced pica could be useful as a behavioral index for the severity of radiation-induced vomiting in rats.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
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| pubmed:issn |
0449-3060
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
43
|
| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
135-41
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| pubmed:dateRevised |
2003-11-14
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| pubmed:meshHeading |
pubmed-meshheading:12238327-Animals,
pubmed-meshheading:12238327-Disease Models, Animal,
pubmed-meshheading:12238327-Male,
pubmed-meshheading:12238327-Pica,
pubmed-meshheading:12238327-Radiation Injuries,
pubmed-meshheading:12238327-Rats,
pubmed-meshheading:12238327-Rats, Wistar,
pubmed-meshheading:12238327-Vomiting,
pubmed-meshheading:12238327-Whole-Body Irradiation
|
| pubmed:year |
2002
|
| pubmed:articleTitle |
Establishment of an animal model for radiation-induced vomiting in rats using pica.
|
| pubmed:affiliation |
Department of Medical Physics, School of Allied Health Sciences, Faculty of Medicine, Osaka University, 1-7, Yamadaoka, Suita, Osaka 565-0871, Japan.
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| pubmed:publicationType |
Journal Article
|