Linked Life Data

12237076

Source:http://linkedlifedata.com/resource/pubmed/id/12237076

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2002-9-18
pubmed:abstractText
We describe a possible clinical interaction between topiramate (TPM) and carbamazepine modified release (CBZ-MR) in patients taking maximum tolerated doses of carbamazepine. Data are presented on 25 patients who contacted the epilepsy nurse specialist telephone helpline for advice after starting treatment with TPM. Thirteen male and 12 female patients, mean age 41 years (range 25-69 years), with localization-related epilepsy contacted the helplines, between November 1999 and March 2001, complaining of symptoms of antiepileptic drug intoxication after starting treatment with TPM. All were taking maximum tolerated doses of CBZ-MR before starting TPM. Sixteen of the patients were taking other antiepileptic drugs concomitantly with CBZ-MR and TPM. Symptoms of intoxication were similar to those previously experienced when maximum tolerated doses of CBZ-MR were exceeded. Symptoms resolved when concomitant CBZ-MR doses were reduced, enabling further dose escalation of TPM. To our knowledge, neither clinical nor pharmacological interactions between CBZ and TPM have been described previously in man. These data suggest that such an interaction may be of clinical importance, and that reduction of the CBZ dose may enable optimization of the dose of TPM, improving seizure control.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1059-1311
pubmed:author
pubmed:issnType
Print
pubmed:volume
11
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
464-7
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
Interaction of topiramate with carbamazepine: two case reports and a review of clinical experience.
pubmed:affiliation
Department of Clinical Neurology, Royal Hallamshire Hospital, Glossop Road, Sheffield S10 2JF, UK.
pubmed:publicationType
Journal Article, Case Reports