Linked Life Data

12234534

Source:http://linkedlifedata.com/resource/pubmed/id/12234534

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2002-9-17
pubmed:abstractText
Filarial nematodes are parasitic worms that cause some of the most devastating of all tropical diseases such as elephantiasis and river blindness. Studies on the inflammatory pathogenesis of filarial disease have shown that endotoxin-like activity derived from endosymbiotic Wolbachia bacteria is the major inflammatory stimulus of filarial nematodes. Wolbachia appear to have evolved as essential symbionts of their filarial nematode hosts. Antibiotic depletion of bacteria shows that they are required for normal fertility and development of the worm and may even protect the parasites from host immunity. In addition to the uncovering of a fascinating symbiotic relationship, this discovery means we can now consider using antibiotics as a new approach to the treatment of filarial diseases.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0188-4409
pubmed:author
pubmed:issnType
Print
pubmed:volume
33
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
422-4
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
Wolbachia endosymbiotic bacteria of filarial nematodes. A new insight into disease pathogenesis and control.
pubmed:affiliation
Division of Molecular and Biochemical Parasitology, Liverpool School of Tropical Medicine, Liverpool, UK. mark.taylor@liverpool.ac.uk
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't