|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0033414,
umls-concept:C0035143,
umls-concept:C0037083,
umls-concept:C0185117,
umls-concept:C0439097,
umls-concept:C1235660,
umls-concept:C1414313,
umls-concept:C1427826,
umls-concept:C1547348,
umls-concept:C1704259,
umls-concept:C1705241,
umls-concept:C1705987,
umls-concept:C1710082,
umls-concept:C1822616,
umls-concept:C2911684
|
|
pubmed:issue |
5
|
|
pubmed:dateCreated |
2002-9-16
|
|
pubmed:abstractText |
The Notch and Epidermal Growth Factor Receptor (EGFR) pathways both regulate proliferation and differentiation, and the cellular response to each is often influenced by the other. Here, we describe a mechanism that links them in a sequential fashion, in the developing compound eye of Drosophila. EGFR activation induces photoreceptor (R cell) differentiation and promotes their expression of Delta. This Notch ligand then induces neighboring cells to become nonneuronal cone cells. ebi and strawberry notch (sno) regulate EGFR-dependent Delta transcription by antagonizing a repressor function of Suppressor of Hairless (Su(H)). Sno binds to Su(H), and Ebi, an F-box/WD40 protein, forms a complex with Su(H) and the corepressor SMRTER. EGFR-activated transcriptional derepression requires ebi and sno, is proteasome-dependent, and correlates with the translocation of SMRTER to the cytoplasm.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Basic Helix-Loop-Helix...,
http://linkedlifedata.com/resource/pubmed/chemical/Cell Cycle Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Drosophila Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/E(spl) region transcript mdelta...,
http://linkedlifedata.com/resource/pubmed/chemical/GTP-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Insect Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Epidermal Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Notch,
http://linkedlifedata.com/resource/pubmed/chemical/Repressor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/ebi protein, Drosophila,
http://linkedlifedata.com/resource/pubmed/chemical/notch protein, Drosophila,
http://linkedlifedata.com/resource/pubmed/chemical/sno protein, Drosophila,
http://linkedlifedata.com/resource/pubmed/chemical/suppressor of Hairless protein...
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Sep
|
|
pubmed:issn |
0092-8674
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
6
|
|
pubmed:volume |
110
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
625-37
|
|
pubmed:dateRevised |
2009-11-19
|
|
pubmed:meshHeading |
pubmed-meshheading:12230979-Animals,
pubmed-meshheading:12230979-Basic Helix-Loop-Helix Transcription Factors,
pubmed-meshheading:12230979-Cell Cycle Proteins,
pubmed-meshheading:12230979-DNA-Binding Proteins,
pubmed-meshheading:12230979-Drosophila,
pubmed-meshheading:12230979-Drosophila Proteins,
pubmed-meshheading:12230979-GTP-Binding Proteins,
pubmed-meshheading:12230979-Insect Proteins,
pubmed-meshheading:12230979-Membrane Proteins,
pubmed-meshheading:12230979-Nuclear Proteins,
pubmed-meshheading:12230979-Photoreceptor Cells, Invertebrate,
pubmed-meshheading:12230979-Receptor, Epidermal Growth Factor,
pubmed-meshheading:12230979-Receptors, Notch,
pubmed-meshheading:12230979-Repressor Proteins,
pubmed-meshheading:12230979-Signal Transduction,
pubmed-meshheading:12230979-Transcription Factors
|
|
pubmed:year |
2002
|
|
pubmed:articleTitle |
An EGFR/Ebi/Sno pathway promotes delta expression by inactivating Su(H)/SMRTER repression during inductive notch signaling.
|
|
pubmed:affiliation |
Department of Biological Chemistry and Department of Human Genetics, Molecular Biology Institute, Los Angeles, CA 90095, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
|
