Linked Life Data

12224583

Source:http://linkedlifedata.com/resource/pubmed/id/12224583

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2002-9-12
pubmed:abstractText
Leishmania Viannia strains from 1,092 patients who acquired dermal leishmaniasis in endemic regions of Colombia were analyzed for expression of species and subgenus specific epitopes. Eight monoclonal antibodies prepared against membranes of the major species of the Viannia subgenus and previously shown to distinguish these species, recognized low molecular mass (< 45kD) membrane components. Thirteen widely but non-uniformly distributed serodemes were identified: one unique to L. panamensis, four unique to L. braziliensis and eight that were common to L. braziliensis and L. guyanensis. Thirty-seven percent of Colombian L. braziliensis strains concomitantly typed by isoenzymes were null, i.e., not recognized by the corresponding species-specific B-16 or B-18 antibodies. No Colombian L. guyanensis strains were recognized by the antibody specific for this species (B-19). In contrast, L. panamensis-specific B-4 and B11 antibodies recognized > 98% of the L. panamensis strains. Null strains of L. braziliensis and L. panamensis were more frequently isolated from mucosal leishmaniasis than strains that expressed species specific epitopes, suggesting that these strains may be more pathogenic.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0002-9637
pubmed:author
pubmed:issnType
Print
pubmed:volume
66
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
738-44
pubmed:dateRevised
2011-9-22
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
Heterogeneity, geographic distribution, and pathogenicity of serodemes of Leishmania viannia in Colombia.
pubmed:affiliation
Centro Internacional de Entrenamiento e Investigaciones Médicas, Cali, Colombia. saravia@cideim.org.co
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't