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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1976-6-2
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pubmed:abstractText |
The time course of DNA binding capacity (DNA-bc) was found to correlate with the clinical course in a group of 21 patients who had biopsy-proven lupus glomerulonephritis and were treated with immunosuppressive agents. Eight patients showed a sequential DNA-bc pattern in which a high titre of anti-DNA antibody was present for a prolonged period of time all having an unfavourable clinical course. Persistently high values of DNA-bc preceded by as much as 10 months evidence of renal deterioration obtained by conventional renal function tests. Thirteen patients showed a low titre of anti-DNA antibody throughout most of their course, 12 having a favourable outcome. An initially high value of DNA-bc had no prognostic significance. These results suggest that the persistence of a high titre of anti-DNA antibody in patients with lupus glomerulonephritis is a poor prognostic sign.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1221925-13611294,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1221925-14202576,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1221925-4106884,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1221925-4123760,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1221925-4131150,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1221925-4174390,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1221925-4580007,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1221925-4599389,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1221925-4693646,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1221925-4866347,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1221925-4947941,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1221925-4996903,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1221925-5821163
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0003-4967
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
34
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
444-50
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:1221925-Adolescent,
pubmed-meshheading:1221925-Adult,
pubmed-meshheading:1221925-Antibody Specificity,
pubmed-meshheading:1221925-Binding Sites, Antibody,
pubmed-meshheading:1221925-DNA,
pubmed-meshheading:1221925-Glomerulonephritis,
pubmed-meshheading:1221925-Humans,
pubmed-meshheading:1221925-Lupus Erythematosus, Systemic,
pubmed-meshheading:1221925-Prognosis,
pubmed-meshheading:1221925-Time Factors
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pubmed:year |
1975
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pubmed:articleTitle |
Prognostic significance of DNA-binding capacity patterns in patients with lupus nephritis.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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