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rdf:type |
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lifeskim:mentions |
umls-concept:C0024432,
umls-concept:C0028953,
umls-concept:C0429403,
umls-concept:C0521447,
umls-concept:C0591833,
umls-concept:C1274040,
umls-concept:C1417708,
umls-concept:C1423613,
umls-concept:C1521761,
umls-concept:C1539081,
umls-concept:C1705525
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|
pubmed:issue |
2
|
|
pubmed:dateCreated |
2002-9-9
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|
pubmed:abstractText |
DNA containing the CpG motif is associated with immunomodulation of the innate immune response. Preexposure of macrophages to CpG DNA elicits a hyporesponsiveness to subsequent lipopolysaccharide (LPS) stimulation. We tested the hypothesis that this effect is due to decreased nuclear translocation of nuclear factor kappaB (NF-kappaB).
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:month |
Aug
|
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pubmed:issn |
0039-6060
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
132
|
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
245-51
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:12219019-Adjuvants, Immunologic,
pubmed-meshheading:12219019-Animals,
pubmed-meshheading:12219019-Cells, Cultured,
pubmed-meshheading:12219019-CpG Islands,
pubmed-meshheading:12219019-DNA-Binding Proteins,
pubmed-meshheading:12219019-Dimerization,
pubmed-meshheading:12219019-I-kappa B Proteins,
pubmed-meshheading:12219019-Lipopolysaccharides,
pubmed-meshheading:12219019-Macrophages,
pubmed-meshheading:12219019-Mice,
pubmed-meshheading:12219019-Mitogen-Activated Protein Kinases,
pubmed-meshheading:12219019-NF-kappa B,
pubmed-meshheading:12219019-Oligonucleotides
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|
pubmed:year |
2002
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|
pubmed:articleTitle |
Preexposure of murine macrophages to CpG-containing oligonucleotides results in nuclear factor kappaB p50 homodimer-associated hyporesponsiveness.
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pubmed:affiliation |
Surgical Infectious Disease Laboratory, Department of Surgery, University of Virginia, Charlottesville 22906, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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