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rdf:type |
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lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0028754,
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0185117,
umls-concept:C0332307,
umls-concept:C0769152,
umls-concept:C1113688,
umls-concept:C1335671,
umls-concept:C1415500,
umls-concept:C2911684
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pubmed:issue |
9
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pubmed:dateCreated |
2002-9-9
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pubmed:abstractText |
We examined the expressions of the prepro-orexin gene in the lateral hypothalamic area (LHA), the genes of the neuropeptide Y (NPY) and proopiomelanocortin (POMC) in the arcuate nucleus (ARC), the orexin type 1 receptor (OX1R) gene in the ventromedial hypothalamic nucleus (VMH) and the orexin type 2 receptor (OX2R) gene in the paraventricular nucleus (PVN) in 6-, 12- and 18-week-old male lean (Fa/?) and obese (fa/fa) Zucker rats, using in situ hybridization histochemistry. The fa/fa rats showed hyperglycemia at 12- and 18-week-old. The prepro-orexin mRNA level in fa/fa rats at 18-week-old and the OX2R mRNA level in fa/fa rats at 12- and 18-week-old were significantly decreased compared to controls. The NPY mRNA levels in fa/fa rats at each time point were significantly increased compared to controls, but the POMC mRNA levels were decreased. Prepro-orexin and OX2R mRNA levels in fa/fa rats pretreated with insulin normalized to the levels found in Fa/? rats. These results suggest that the regulation of prepro-orexin gene expression might be independent of the regulation of the NPY and POMC genes in the ARC in fa/fa rats.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/Intracellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/Neuropeptides,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Precursors,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, G-Protein-Coupled,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Neuropeptide,
http://linkedlifedata.com/resource/pubmed/chemical/orexin receptors,
http://linkedlifedata.com/resource/pubmed/chemical/orexins
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0196-9781
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
23
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1689-96
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:12217430-Animals,
pubmed-meshheading:12217430-Body Weight,
pubmed-meshheading:12217430-Carrier Proteins,
pubmed-meshheading:12217430-Hyperglycemia,
pubmed-meshheading:12217430-In Situ Hybridization,
pubmed-meshheading:12217430-Insulin,
pubmed-meshheading:12217430-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:12217430-Male,
pubmed-meshheading:12217430-Neuropeptides,
pubmed-meshheading:12217430-Paraventricular Hypothalamic Nucleus,
pubmed-meshheading:12217430-Protein Precursors,
pubmed-meshheading:12217430-RNA, Messenger,
pubmed-meshheading:12217430-Rats,
pubmed-meshheading:12217430-Rats, Zucker,
pubmed-meshheading:12217430-Receptors, G-Protein-Coupled,
pubmed-meshheading:12217430-Receptors, Neuropeptide,
pubmed-meshheading:12217430-Time Factors,
pubmed-meshheading:12217430-Ventromedial Hypothalamic Nucleus
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pubmed:year |
2002
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pubmed:articleTitle |
Expressions of the prepro-orexin and orexin type 2 receptor genes in obese rat.
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pubmed:affiliation |
Department of Physiology, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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