Source:http://linkedlifedata.com/resource/pubmed/id/12216941
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2-3
|
| pubmed:dateCreated |
2002-9-9
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| pubmed:abstractText |
In this review, we describe the evidence from which the existence of non-MHC histocompatibility (H) antigens was deduced, the clinical setting of bone marrow transplantation in which they are important targets for T cell responses, and the current understanding of their molecular identity. We list the peptide epitopes, their MHC restriction molecules and the genes encoding them, of the human and murine minor H antigens now identified at the molecular level. Identification of the peptide epitopes allows T cell responses to these antigens following transplantation of MHC-matched, minor H-mismatched tissues to be enumerated using tetramers and elispot assays. This will facilitate analysis of correlations with HVG, GVH and GVL reactions in vivo. The potential to use minor H peptides to modulate in vivo responses to minor H antigens is discussed. Factors controlling immunodominance of T cell responses to one or a few of many potential minor H antigens remain to be elucidated but are important for making predictions of in vivo HVG, GVH and GVL responses and tailoring therapy after HLA-matched BMT and DLI.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0966-3274
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
10
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
115-23
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| pubmed:dateRevised |
2005-11-16
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| pubmed:meshHeading |
pubmed-meshheading:12216941-Amino Acid Sequence,
pubmed-meshheading:12216941-Animals,
pubmed-meshheading:12216941-Antigen Presentation,
pubmed-meshheading:12216941-Bone Marrow Transplantation,
pubmed-meshheading:12216941-Female,
pubmed-meshheading:12216941-Graft vs Host Reaction,
pubmed-meshheading:12216941-Graft vs Leukemia Effect,
pubmed-meshheading:12216941-Hematopoietic Stem Cell Transplantation,
pubmed-meshheading:12216941-Host vs Graft Reaction,
pubmed-meshheading:12216941-Humans,
pubmed-meshheading:12216941-Immunization,
pubmed-meshheading:12216941-Immunodominant Epitopes,
pubmed-meshheading:12216941-Male,
pubmed-meshheading:12216941-Mice,
pubmed-meshheading:12216941-Minor Histocompatibility Antigens,
pubmed-meshheading:12216941-Molecular Sequence Data,
pubmed-meshheading:12216941-Peptide Fragments,
pubmed-meshheading:12216941-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:12216941-Transplantation Immunology
|
| pubmed:year |
2002
|
| pubmed:articleTitle |
Minor H antigens: genes and peptides.
|
| pubmed:affiliation |
MRC Clinical Sciences Centre, Imperial College Faculty of Medicine, Hammersmith Hospital, London, UK. elizabeth.simpson@csc.mrc.ac.uk
|
| pubmed:publicationType |
Journal Article,
Review
|