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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2002-9-4
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pubmed:abstractText |
Tobacco exposure is an established risk factor for head and neck squamous cell carcinoma (HNSCC). Benzo[alpha]pyrene diol expoxide (BPDE), a main metabolic product of the tobacco smoke constituent benzo[alpha]pyrene, induces chromosomal aberrations at specific loci. Chromosomal aberrations in peripheral blood lymphocytes (PBLs) induced by BPDE may reflect individuals' genetic susceptibility to tobacco carcinogens.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0008-543X
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2002 American Cancer Society.
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
95
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
563-8
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:12209748-7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide,
pubmed-meshheading:12209748-Aged,
pubmed-meshheading:12209748-Carcinogens,
pubmed-meshheading:12209748-Carcinoma, Squamous Cell,
pubmed-meshheading:12209748-Chromosome Aberrations,
pubmed-meshheading:12209748-Chromosomes, Human, Pair 3,
pubmed-meshheading:12209748-Female,
pubmed-meshheading:12209748-Genetic Predisposition to Disease,
pubmed-meshheading:12209748-Genetic Testing,
pubmed-meshheading:12209748-Head and Neck Neoplasms,
pubmed-meshheading:12209748-Humans,
pubmed-meshheading:12209748-In Situ Hybridization, Fluorescence,
pubmed-meshheading:12209748-Lymphocytes,
pubmed-meshheading:12209748-Male,
pubmed-meshheading:12209748-Middle Aged,
pubmed-meshheading:12209748-Predictive Value of Tests
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pubmed:year |
2002
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pubmed:articleTitle |
BPDE-induced lymphocytic 3p21.3 aberrations may predict head and neck carcinoma risk.
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pubmed:affiliation |
Department of Epidemiology, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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