| pubmed-article:12207026 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12207026 | lifeskim:mentions | umls-concept:C0085536 | lld:lifeskim |
| pubmed-article:12207026 | lifeskim:mentions | umls-concept:C1456820 | lld:lifeskim |
| pubmed-article:12207026 | lifeskim:mentions | umls-concept:C1412186 | lld:lifeskim |
| pubmed-article:12207026 | lifeskim:mentions | umls-concept:C1419105 | lld:lifeskim |
| pubmed-article:12207026 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:12207026 | lifeskim:mentions | umls-concept:C0796679 | lld:lifeskim |
| pubmed-article:12207026 | lifeskim:mentions | umls-concept:C0332120 | lld:lifeskim |
| pubmed-article:12207026 | lifeskim:mentions | umls-concept:C0723595 | lld:lifeskim |
| pubmed-article:12207026 | pubmed:issue | 45 | lld:pubmed |
| pubmed-article:12207026 | pubmed:dateCreated | 2002-11-4 | lld:pubmed |
| pubmed-article:12207026 | pubmed:abstractText | Tumor necrosis factor alpha-convertase (TACE) is a metalloprotease-disintegrin involved in the ectodomain shedding of several proteins and is critical for proper murine development. TACE-mediated ectodomain shedding is regulated, and the cytoplasmic domain of TACE contains several potential signaling motifs, suggesting that this domain may play a role in regulating the metalloprotease activity. Here we report that the protein-tyrosine phosphatase PTPH1, which contains both a band 4.1 domain and a single PDZ domain, can interact with the cytoplasmic domain of TACE. The interaction was initially observed in a yeast two-hybrid screen and was confirmed using an in vitro binding assay and co-immunoprecipitations from eukaryotic cell extracts. The interaction is mediated via binding of the PDZ domain of PTPH1 to the COOH terminus of TACE. The latter represents a novel group I PDZ binding sequence characterized by a terminal cysteine residue. In co-expression experiments, significantly lower levels of TACE were observed in the presence of catalytically active forms of PTPH1 compared with catalytically inactive forms of PTPH1. Furthermore, phorbol ester-stimulated shedding of the TACE substrate tumor necrosis factor-alpha was decreased in cells expressing catalytically active PTPH1 compared with inactive PTPH1. Taken together, these results suggest that PTPH1 may be a negative regulator of TACE levels and function, and thus provide the first evidence for the regulation of TACE through a cytoplasmic protein. | lld:pubmed |
| pubmed-article:12207026 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12207026 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12207026 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12207026 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12207026 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12207026 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12207026 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12207026 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12207026 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12207026 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12207026 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12207026 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12207026 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12207026 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12207026 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12207026 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12207026 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12207026 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12207026 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:12207026 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:12207026 | pubmed:author | pubmed-author:BlobelCarl... | lld:pubmed |
| pubmed-article:12207026 | pubmed:author | pubmed-author:ZhengYufangY | lld:pubmed |
| pubmed-article:12207026 | pubmed:author | pubmed-author:SchlondorffJo... | lld:pubmed |
| pubmed-article:12207026 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12207026 | pubmed:day | 8 | lld:pubmed |
| pubmed-article:12207026 | pubmed:volume | 277 | lld:pubmed |
| pubmed-article:12207026 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12207026 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12207026 | pubmed:pagination | 42463-70 | lld:pubmed |
| pubmed-article:12207026 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:12207026 | pubmed:meshHeading | pubmed-meshheading:12207026... | lld:pubmed |
| pubmed-article:12207026 | pubmed:meshHeading | pubmed-meshheading:12207026... | lld:pubmed |
| pubmed-article:12207026 | pubmed:meshHeading | pubmed-meshheading:12207026... | lld:pubmed |
| pubmed-article:12207026 | pubmed:meshHeading | pubmed-meshheading:12207026... | lld:pubmed |
| pubmed-article:12207026 | pubmed:meshHeading | pubmed-meshheading:12207026... | lld:pubmed |
| pubmed-article:12207026 | pubmed:meshHeading | pubmed-meshheading:12207026... | lld:pubmed |
| pubmed-article:12207026 | pubmed:meshHeading | pubmed-meshheading:12207026... | lld:pubmed |
| pubmed-article:12207026 | pubmed:meshHeading | pubmed-meshheading:12207026... | lld:pubmed |
| pubmed-article:12207026 | pubmed:meshHeading | pubmed-meshheading:12207026... | lld:pubmed |
| pubmed-article:12207026 | pubmed:meshHeading | pubmed-meshheading:12207026... | lld:pubmed |
| pubmed-article:12207026 | pubmed:meshHeading | pubmed-meshheading:12207026... | lld:pubmed |
| pubmed-article:12207026 | pubmed:meshHeading | pubmed-meshheading:12207026... | lld:pubmed |
| pubmed-article:12207026 | pubmed:meshHeading | pubmed-meshheading:12207026... | lld:pubmed |
| pubmed-article:12207026 | pubmed:meshHeading | pubmed-meshheading:12207026... | lld:pubmed |
| pubmed-article:12207026 | pubmed:meshHeading | pubmed-meshheading:12207026... | lld:pubmed |
| pubmed-article:12207026 | pubmed:meshHeading | pubmed-meshheading:12207026... | lld:pubmed |
| pubmed-article:12207026 | pubmed:meshHeading | pubmed-meshheading:12207026... | lld:pubmed |
| pubmed-article:12207026 | pubmed:meshHeading | pubmed-meshheading:12207026... | lld:pubmed |
| pubmed-article:12207026 | pubmed:meshHeading | pubmed-meshheading:12207026... | lld:pubmed |
| pubmed-article:12207026 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12207026 | pubmed:articleTitle | Evidence for regulation of the tumor necrosis factor alpha-convertase (TACE) by protein-tyrosine phosphatase PTPH1. | lld:pubmed |
| pubmed-article:12207026 | pubmed:affiliation | Graduate Program in Physiology, Biophysics and Molecular Medicine, Weill Graduate School of Medical Science of Cornell University, New York, New York 10021, USA. | lld:pubmed |
| pubmed-article:12207026 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12207026 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:12207026 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:5774 | entrezgene:pubmed | pubmed-article:12207026 | lld:entrezgene |
| entrez-gene:6868 | entrezgene:pubmed | pubmed-article:12207026 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:12207026 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:12207026 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:12207026 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12207026 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12207026 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12207026 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12207026 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12207026 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12207026 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12207026 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12207026 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12207026 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12207026 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12207026 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12207026 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12207026 | lld:pubmed |
