Source:http://linkedlifedata.com/resource/pubmed/id/12200895
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
437
|
| pubmed:dateCreated |
2002-8-30
|
| pubmed:abstractText |
There is mounting evidence suggesting that infection with respiratory syncytial virus (RSV) in early life increases the risk of developing reactive airway disease (RAD) later in childhood. A recent prospective study demonstrated that children hospitalized with RSV bronchiolitis in infancy face a significantly increased risk of recurrent wheezing and allergy at least until the age of 7 y that is independent of hereditary factors. Proposed mechanisms for this link include immune dysregulation, in which RSV-specific IgE or an imbalance between T-lymphocyte-dependent immune pathways may be involved, and abnormal neural control, in which the non-adrenergic, non-cholinergic pathways are altered by RSV infection. More recent studies suggest that immune and neural mechanisms may be linked and that post-RSV airway inflammation may be explained, at least in part, on the basis of these neuroimmune interactions. CONCLUSION: Passive immunoprophylaxis may protect against persistent viral-induced inflammation of the respiratory tract, long-term changes in pulmonary function and increased frequency of RAD episodes.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0803-5326
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
91
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
6-11
|
| pubmed:dateRevised |
2008-5-12
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| pubmed:meshHeading |
pubmed-meshheading:12200895-Animals,
pubmed-meshheading:12200895-Asthma,
pubmed-meshheading:12200895-Biopsy, Needle,
pubmed-meshheading:12200895-Bronchial Hyperreactivity,
pubmed-meshheading:12200895-Bronchiolitis,
pubmed-meshheading:12200895-Disease Models, Animal,
pubmed-meshheading:12200895-Female,
pubmed-meshheading:12200895-Humans,
pubmed-meshheading:12200895-Immunohistochemistry,
pubmed-meshheading:12200895-Male,
pubmed-meshheading:12200895-Mice,
pubmed-meshheading:12200895-Mice, Knockout,
pubmed-meshheading:12200895-Molecular Biology,
pubmed-meshheading:12200895-Neural Pathways,
pubmed-meshheading:12200895-Prognosis,
pubmed-meshheading:12200895-Prospective Studies,
pubmed-meshheading:12200895-Rats,
pubmed-meshheading:12200895-Rats, Inbred F344,
pubmed-meshheading:12200895-Respiratory Syncytial Virus Infections,
pubmed-meshheading:12200895-Risk Assessment,
pubmed-meshheading:12200895-Sensitivity and Specificity
|
| pubmed:year |
2002
|
| pubmed:articleTitle |
Origins of reactive airways disease in early life: do viral infections play a role?
|
| pubmed:affiliation |
Batchelor Children's Research Institute, Pediatric Pulmonology and Cystic Fibrosis Center, University of Miami School of Medicine, 1580 NW 10th Ave. (D-820), Miami, FL 33136, USA. gpiedimo@med.miami.edu
|
| pubmed:publicationType |
Journal Article,
Review
|