Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
17
pubmed:dateCreated
2002-8-28
pubmed:abstractText
The calcium-binding protein DREAM binds specifically to DRE sites in the DNA and represses transcription of target genes. Derepression at DRE sites following PKA activation depends on a specific interaction between alphaCREM and DREAM. Two leucine-charged residue-rich domains (LCD) located in the kinase-inducible domain (KID) and in the leucine zipper of alphaCREM and two LCDs in DREAM participate in a two-site interaction that results in the loss of DREAM binding to DRE sites and derepression. Since the LCD motif located within the KID in CREM is also present in CREB, and maps in a region critical for the recruitment of CBP, we investigated whether DREAM may affect CRE-dependent transcription. Here we show that in the absence of Ca2+ DREAM binds to the LCD in the KID of CREB. As a result, DREAM impairs recruitment of CBP by phospho CREB and blocks CBP-mediated transactivation at CRE sites in a Ca2+-dependent manner. Thus, Ca2+-dependent interactions between DREAM and CREB represent a novel point of cross-talk between cAMP and Ca2+ signalling pathways in the nucleus.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/12198160-10078534, http://linkedlifedata.com/resource/pubmed/commentcorrection/12198160-10573424, http://linkedlifedata.com/resource/pubmed/commentcorrection/12198160-10598580, http://linkedlifedata.com/resource/pubmed/commentcorrection/12198160-10669732, http://linkedlifedata.com/resource/pubmed/commentcorrection/12198160-10676964, http://linkedlifedata.com/resource/pubmed/commentcorrection/12198160-10887150, http://linkedlifedata.com/resource/pubmed/commentcorrection/12198160-11094064, http://linkedlifedata.com/resource/pubmed/commentcorrection/12198160-11094091, http://linkedlifedata.com/resource/pubmed/commentcorrection/12198160-11108959, http://linkedlifedata.com/resource/pubmed/commentcorrection/12198160-11259575, http://linkedlifedata.com/resource/pubmed/commentcorrection/12198160-11278424, http://linkedlifedata.com/resource/pubmed/commentcorrection/12198160-11279224, http://linkedlifedata.com/resource/pubmed/commentcorrection/12198160-11287421, http://linkedlifedata.com/resource/pubmed/commentcorrection/12198160-11296231, http://linkedlifedata.com/resource/pubmed/commentcorrection/12198160-11331593, http://linkedlifedata.com/resource/pubmed/commentcorrection/12198160-11463380, http://linkedlifedata.com/resource/pubmed/commentcorrection/12198160-11535596, http://linkedlifedata.com/resource/pubmed/commentcorrection/12198160-11535812, http://linkedlifedata.com/resource/pubmed/commentcorrection/12198160-11572963, http://linkedlifedata.com/resource/pubmed/commentcorrection/12198160-11701890, http://linkedlifedata.com/resource/pubmed/commentcorrection/12198160-11788589, http://linkedlifedata.com/resource/pubmed/commentcorrection/12198160-11970865, http://linkedlifedata.com/resource/pubmed/commentcorrection/12198160-1354612, http://linkedlifedata.com/resource/pubmed/commentcorrection/12198160-1646483, http://linkedlifedata.com/resource/pubmed/commentcorrection/12198160-1847666, http://linkedlifedata.com/resource/pubmed/commentcorrection/12198160-2154851, http://linkedlifedata.com/resource/pubmed/commentcorrection/12198160-2875459, http://linkedlifedata.com/resource/pubmed/commentcorrection/12198160-2900470, http://linkedlifedata.com/resource/pubmed/commentcorrection/12198160-3018542, http://linkedlifedata.com/resource/pubmed/commentcorrection/12198160-3779841, http://linkedlifedata.com/resource/pubmed/commentcorrection/12198160-558524, http://linkedlifedata.com/resource/pubmed/commentcorrection/12198160-7706240, http://linkedlifedata.com/resource/pubmed/commentcorrection/12198160-7798217, http://linkedlifedata.com/resource/pubmed/commentcorrection/12198160-7913207, http://linkedlifedata.com/resource/pubmed/commentcorrection/12198160-7958915, http://linkedlifedata.com/resource/pubmed/commentcorrection/12198160-8028671, http://linkedlifedata.com/resource/pubmed/commentcorrection/12198160-8065343, http://linkedlifedata.com/resource/pubmed/commentcorrection/12198160-8413673, http://linkedlifedata.com/resource/pubmed/commentcorrection/12198160-8552098, http://linkedlifedata.com/resource/pubmed/commentcorrection/12198160-8689562, http://linkedlifedata.com/resource/pubmed/commentcorrection/12198160-8943032, http://linkedlifedata.com/resource/pubmed/commentcorrection/12198160-8978696, http://linkedlifedata.com/resource/pubmed/commentcorrection/12198160-9192892, http://linkedlifedata.com/resource/pubmed/commentcorrection/12198160-9192902, http://linkedlifedata.com/resource/pubmed/commentcorrection/12198160-9413984, http://linkedlifedata.com/resource/pubmed/commentcorrection/12198160-9727976, http://linkedlifedata.com/resource/pubmed/commentcorrection/12198160-9771752, http://linkedlifedata.com/resource/pubmed/commentcorrection/12198160-9819380
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Caffeine, http://linkedlifedata.com/resource/pubmed/chemical/Calcium, http://linkedlifedata.com/resource/pubmed/chemical/Calcium-Binding Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Cyclic AMP Response Element..., http://linkedlifedata.com/resource/pubmed/chemical/Cyclic AMP Response..., http://linkedlifedata.com/resource/pubmed/chemical/Cyclic AMP-Dependent Protein Kinases, http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins, http://linkedlifedata.com/resource/pubmed/chemical/KCNIP3 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Kv Channel-Interacting Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Repressor Proteins
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0261-4189
pubmed:author
pubmed:issnType
Print
pubmed:day
2
pubmed:volume
21
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
4583-92
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
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