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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2002-8-28
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pubmed:abstractText |
B cell terminal differentiation is associated with the onset of high-level antibody secretion and cell cycle arrest. Here the cyclin-dependent kinase (CDK) inhibitor p18(INK4c) is shown to be required within B cells for both terminating cell proliferation and differentiation of functional plasma cells. In its absence, B cells hyperproliferate in germinal centers and extrafollicular foci in response to T-dependent antigens but serum antibody titers are severely reduced, despite unimpaired germinal center formation, class switch recombination, variable region-directed hypermutation, and differentiation to antibody-containing plasmacytoid cells. The novel link between cell cycle control and plasma cell differentiation may, at least in part, relate to p18(INK4c) inhibition of CDK6. Cell cycle arrest mediated by p18(INK4C) is therefore requisite for the generation of functional plasma cells.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD40,
http://linkedlifedata.com/resource/pubmed/chemical/Cdk6 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Cdkn2c protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Cell Cycle Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinase 6,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinase Inhibitor...,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1074-7613
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pubmed:author |
pubmed-author:Chen-KiangSelinaS,
pubmed-author:ChenMeihongM,
pubmed-author:CunninghamAdam FAF,
pubmed-author:FranklinDavid SDS,
pubmed-author:LeeHayyoungH,
pubmed-author:MacLennanIan C MIC,
pubmed-author:QinXiao-FengXF,
pubmed-author:ScottJ PJPJr,
pubmed-author:ToellnerKai-MichaelKM,
pubmed-author:TourignyMichelle RMR,
pubmed-author:Ursini-SiegelJosieJ,
pubmed-author:XiongYueY
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pubmed:issnType |
Print
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pubmed:volume |
17
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
179-89
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:12196289-Animals,
pubmed-meshheading:12196289-Antibody Formation,
pubmed-meshheading:12196289-Antigens, CD40,
pubmed-meshheading:12196289-Apoptosis,
pubmed-meshheading:12196289-Cell Cycle,
pubmed-meshheading:12196289-Cell Cycle Proteins,
pubmed-meshheading:12196289-Cell Differentiation,
pubmed-meshheading:12196289-Cell Division,
pubmed-meshheading:12196289-Cyclin-Dependent Kinase 6,
pubmed-meshheading:12196289-Cyclin-Dependent Kinase Inhibitor p18,
pubmed-meshheading:12196289-Cyclin-Dependent Kinases,
pubmed-meshheading:12196289-Enzyme Inhibitors,
pubmed-meshheading:12196289-Germinal Center,
pubmed-meshheading:12196289-Mice,
pubmed-meshheading:12196289-Mice, Knockout,
pubmed-meshheading:12196289-Plasma Cells,
pubmed-meshheading:12196289-Protein-Serine-Threonine Kinases,
pubmed-meshheading:12196289-Signal Transduction,
pubmed-meshheading:12196289-Tumor Suppressor Proteins
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pubmed:year |
2002
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pubmed:articleTitle |
CDK inhibitor p18(INK4c) is required for the generation of functional plasma cells.
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pubmed:affiliation |
Department of Pathology, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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