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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2002-8-26
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pubmed:databankReference |
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pubmed:abstractText |
Elevation of cAMP can overcome myelin inhibitors to encourage regeneration of the CNS. We show that a consequence of elevated cAMP is the synthesis of polyamines, resulting from an up-regulation of Arginase I, a key enzyme in their synthesis. Inhibiting polyamine synthesis blocks the cAMP effect on regeneration. Either over-expression of Arginase I or exogenous polyamines can overcome inhibition by MAG and by myelin in general. While MAG/myelin support the growth of young DRG neurons, they become inhibitory as DRGs mature. Endogenous Arginase I levels are high in young DRGs but drop spontaneously at an age that coincides with the switch from promotion to inhibition by MAG/myelin. Over-expressing Arginase I in maturing DRGs blocks that switch. Arginase I and polyamines are more specific targets than cAMP for intervention to encourage regeneration after CNS injury.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Arginase,
http://linkedlifedata.com/resource/pubmed/chemical/Brain-Derived Neurotrophic Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Bucladesine,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic AMP,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Complementary,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Myelin-Associated Glycoprotein,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Growth Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Polyamines,
http://linkedlifedata.com/resource/pubmed/chemical/Putrescine
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0896-6273
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
35
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
711-9
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:12194870-Animals,
pubmed-meshheading:12194870-Arginase,
pubmed-meshheading:12194870-Brain-Derived Neurotrophic Factor,
pubmed-meshheading:12194870-Bucladesine,
pubmed-meshheading:12194870-CHO Cells,
pubmed-meshheading:12194870-Central Nervous System,
pubmed-meshheading:12194870-Cricetinae,
pubmed-meshheading:12194870-Cyclic AMP,
pubmed-meshheading:12194870-DNA, Complementary,
pubmed-meshheading:12194870-Down-Regulation,
pubmed-meshheading:12194870-Enzyme Inhibitors,
pubmed-meshheading:12194870-Ganglia, Spinal,
pubmed-meshheading:12194870-Growth Cones,
pubmed-meshheading:12194870-Molecular Sequence Data,
pubmed-meshheading:12194870-Myelin Sheath,
pubmed-meshheading:12194870-Myelin-Associated Glycoprotein,
pubmed-meshheading:12194870-Nerve Growth Factors,
pubmed-meshheading:12194870-Nerve Regeneration,
pubmed-meshheading:12194870-Polyamines,
pubmed-meshheading:12194870-Putrescine,
pubmed-meshheading:12194870-Rats,
pubmed-meshheading:12194870-Transcription, Genetic,
pubmed-meshheading:12194870-Transfection,
pubmed-meshheading:12194870-Up-Regulation
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pubmed:year |
2002
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pubmed:articleTitle |
Arginase I and polyamines act downstream from cyclic AMP in overcoming inhibition of axonal growth MAG and myelin in vitro.
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pubmed:affiliation |
Biology Department, Hunter College, City University of New York, 695 Park Avenue, New York, NY 10024, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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