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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2002-8-22
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pubmed:abstractText |
A primary defect of the tight junctions and, hence, increased intestinal epithelial permeability has been proposed as a basic pathogenic event in Crohn's disease. Challenge of the mucosal immune system by the commensal gut flora would then result in chronic inflammation. Alternatively, increased permeability could be the result of inflammation. Our aim was to study intestinal permeability in refractory Crohn's disease before and after treatment with monoclonal chimeric antibodies directed against tumor necrosis factor (TNF) to investigate whether the abnormal permeability persists after control of inflammation.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0002-9270
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
97
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2000-4
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pubmed:dateRevised |
2011-1-14
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pubmed:meshHeading |
pubmed-meshheading:12190167-Adult,
pubmed-meshheading:12190167-Aged,
pubmed-meshheading:12190167-Antibodies, Monoclonal,
pubmed-meshheading:12190167-C-Reactive Protein,
pubmed-meshheading:12190167-Case-Control Studies,
pubmed-meshheading:12190167-Chromium Radioisotopes,
pubmed-meshheading:12190167-Crohn Disease,
pubmed-meshheading:12190167-Edetic Acid,
pubmed-meshheading:12190167-Female,
pubmed-meshheading:12190167-Gastrointestinal Agents,
pubmed-meshheading:12190167-Humans,
pubmed-meshheading:12190167-Intestinal Mucosa,
pubmed-meshheading:12190167-Male,
pubmed-meshheading:12190167-Middle Aged,
pubmed-meshheading:12190167-Permeability,
pubmed-meshheading:12190167-Statistics, Nonparametric,
pubmed-meshheading:12190167-Treatment Outcome,
pubmed-meshheading:12190167-Tumor Necrosis Factor-alpha
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pubmed:year |
2002
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pubmed:articleTitle |
Anti-tumor necrosis factor treatment restores the gut barrier in Crohn's disease.
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pubmed:affiliation |
Department of Gastroenterology, University Hospital Gasthuisberg, Catholic University Leuven, Leuven, Belgium.
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pubmed:publicationType |
Journal Article
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