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pubmed:abstractText |
Activation of the neuronal sigma(1) (sigma(1)) receptor potentiates calcium mobilization, leading to effective modulation of postsynaptic responses to neurotransmitters. At the behavioral level, sigma(1) agonists modulate learning, response to stress and depression. In particular, the selective sigma(1) agonist igmesine reduced immobility in the forced swimming test.
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pubmed:affiliation |
Département de Biochimie/Enzymologie, Pfizer GRD-Fresnes, 3/9, rue de la Loge, BP 100, 94265 Fresnes Cedex, France.
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