| pubmed-article:12181747 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12181747 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:12181747 | lifeskim:mentions | umls-concept:C0109317 | lld:lifeskim |
| pubmed-article:12181747 | lifeskim:mentions | umls-concept:C1705767 | lld:lifeskim |
| pubmed-article:12181747 | lifeskim:mentions | umls-concept:C0023448 | lld:lifeskim |
| pubmed-article:12181747 | lifeskim:mentions | umls-concept:C0007587 | lld:lifeskim |
| pubmed-article:12181747 | lifeskim:mentions | umls-concept:C0752312 | lld:lifeskim |
| pubmed-article:12181747 | lifeskim:mentions | umls-concept:C1370600 | lld:lifeskim |
| pubmed-article:12181747 | lifeskim:mentions | umls-concept:C0752313 | lld:lifeskim |
| pubmed-article:12181747 | lifeskim:mentions | umls-concept:C1366882 | lld:lifeskim |
| pubmed-article:12181747 | lifeskim:mentions | umls-concept:C1150579 | lld:lifeskim |
| pubmed-article:12181747 | lifeskim:mentions | umls-concept:C1333340 | lld:lifeskim |
| pubmed-article:12181747 | lifeskim:mentions | umls-concept:C1705791 | lld:lifeskim |
| pubmed-article:12181747 | lifeskim:mentions | umls-concept:C1704259 | lld:lifeskim |
| pubmed-article:12181747 | lifeskim:mentions | umls-concept:C1720920 | lld:lifeskim |
| pubmed-article:12181747 | lifeskim:mentions | umls-concept:C1705987 | lld:lifeskim |
| pubmed-article:12181747 | lifeskim:mentions | umls-concept:C1517945 | lld:lifeskim |
| pubmed-article:12181747 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:12181747 | pubmed:dateCreated | 2002-8-15 | lld:pubmed |
| pubmed-article:12181747 | pubmed:abstractText | MEK/ERK-mediated signals have recently been found to inhibit Fas-mediated cell death through inhibition of caspase-8 activity. It remains unknown whether MEK/ERK-mediated signals affect ionizing radiation (IR)-induced cell death. Here we demonstrate that MEK/ERK-mediated signals selectively inhibit IR-induced loss of mitochondrial membrane potential (DeltaPsi(m)) and subsequent cell death. In Jurkat cells, TPA strongly activated ERK and inhibited the IR-induced caspase-8/Bid cleavage and the loss of DeltaPsi(m). The inhibitory effect of TPA was mostly abrogated by pretreatment of a specific MEK inhibitor PD98059, indicating that the effect depends upon MEK/ERK-mediated signals. Moreover, BAF-B03 transfectants expressing IL-2 receptor (IL-2R) beta(c) chain lacking the acidic region, which is responsible for MEK/ERK-mediated signals, revealed higher sensitivity to IR than the transfectants expressing wild-type IL-2R. Interestingly, the signals could neither protect the DeltaPsi(m) loss nor cell death in UV-irradiated cells. These data imply that the anti-apoptotic effect of MEK/ERK-mediated signals appears to selectively inhibit the IR-induced cell death through protection of the DeltaPsi(m) loss. Our data enlighten an anti-apoptotic function of MEK/ERK pathway against IR-induced apoptosis, thereby implying its contribution to radioresistance. | lld:pubmed |
| pubmed-article:12181747 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12181747 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12181747 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12181747 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12181747 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12181747 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12181747 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12181747 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12181747 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12181747 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12181747 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12181747 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12181747 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12181747 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12181747 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12181747 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12181747 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:12181747 | pubmed:issn | 1350-9047 | lld:pubmed |
| pubmed-article:12181747 | pubmed:author | pubmed-author:ImaiKK | lld:pubmed |
| pubmed-article:12181747 | pubmed:author | pubmed-author:EndoTT | lld:pubmed |
| pubmed-article:12181747 | pubmed:author | pubmed-author:AdachiMM | lld:pubmed |
| pubmed-article:12181747 | pubmed:author | pubmed-author:SakataKK | lld:pubmed |
| pubmed-article:12181747 | pubmed:author | pubmed-author:TakekawaMM | lld:pubmed |
| pubmed-article:12181747 | pubmed:author | pubmed-author:HareyamaMM | lld:pubmed |
| pubmed-article:12181747 | pubmed:author | pubmed-author:ShonaiTT | lld:pubmed |
| pubmed-article:12181747 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12181747 | pubmed:volume | 9 | lld:pubmed |
| pubmed-article:12181747 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12181747 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12181747 | pubmed:pagination | 963-71 | lld:pubmed |
| pubmed-article:12181747 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:12181747 | pubmed:meshHeading | pubmed-meshheading:12181747... | lld:pubmed |
| pubmed-article:12181747 | pubmed:meshHeading | pubmed-meshheading:12181747... | lld:pubmed |
| pubmed-article:12181747 | pubmed:meshHeading | pubmed-meshheading:12181747... | lld:pubmed |
| pubmed-article:12181747 | pubmed:meshHeading | pubmed-meshheading:12181747... | lld:pubmed |
| pubmed-article:12181747 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12181747 | pubmed:articleTitle | MEK/ERK pathway protects ionizing radiation-induced loss of mitochondrial membrane potential and cell death in lymphocytic leukemia cells. | lld:pubmed |
| pubmed-article:12181747 | pubmed:affiliation | Department of Radiology, Sapporo Medical University School of Medicine, S-1, W-16, Chuo-ku, Sapporo, 060-8543, Japan. | lld:pubmed |
| pubmed-article:12181747 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12181747 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12181747 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12181747 | lld:pubmed |
