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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
42
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pubmed:dateCreated |
2002-10-15
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pubmed:abstractText |
Liver X receptors (LXR) belong to the nuclear receptor superfamily that can regulate important lipid metabolic pathways. The plasma phospholipid transfer protein (PLTP) is known to mediate transfer of phospholipids from triglyceride-rich lipoproteins to high density lipoprotein (HDL) and plays a critical role in HDL metabolism. We report here that a specific LXR agonist, T0901317, elevated HDL cholesterol and phospholipid in C57/BL6 mice and generated enlarged HDL particles that were enriched in cholesterol, ApoAI, ApoE, and phospholipid. The appearance of these HDL particles upon oral dosing of T0901317 in C57/BL6 mice was closely correlated with the increased plasma PLTP activity and liver PLTP mRNA levels. Nuclear run-on assay indicated that the effect of LXR agonist on PLTP expression was at the transcriptional level. In mouse peritoneal macrophage cells, PLTP expression was also up-regulated by the LXR/RXR (retinoid X receptor) heterodimer. However, cholesterol efflux in mouse peritoneal macrophage cells from PLTP-deficient mice (PLTP0) was not significantly different from wild type animals. Although in PLTP-deficient mice, the induction of HDL cholesterol as well as HDL particle size increase persisted, the extent of the induction was greatly attenuated. We conclude that PLTP is a direct target gene of LXRs in vivo and plays an important role in LXR agonist-mediated HDL cholesterol and size increase in mice.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anticholesteremic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol, HDL,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Hydrocarbons, Fluorinated,
http://linkedlifedata.com/resource/pubmed/chemical/Ligands,
http://linkedlifedata.com/resource/pubmed/chemical/Lipoproteins, HDL,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Orphan Nuclear Receptors,
http://linkedlifedata.com/resource/pubmed/chemical/Phospholipid Transfer Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Phospholipids,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cytoplasmic and Nuclear,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Retinoic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Thyroid Hormone,
http://linkedlifedata.com/resource/pubmed/chemical/Sulfonamides,
http://linkedlifedata.com/resource/pubmed/chemical/TO-901317,
http://linkedlifedata.com/resource/pubmed/chemical/liver X receptor
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0021-9258
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pubmed:author |
pubmed-author:BenschWilliam RWR,
pubmed-author:BeyerThomas PTP,
pubmed-author:CaoGuoqingG,
pubmed-author:EachoPatrick IPI,
pubmed-author:GaoHongH,
pubmed-author:JiangXian-ChengXC,
pubmed-author:KauffmanRaymond FRF,
pubmed-author:LiangYuY,
pubmed-author:RyanTimothy PTP,
pubmed-author:SchmidtRobert JRJ,
pubmed-author:YangXiao PingXP,
pubmed-author:ZhangYouyanY
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pubmed:issnType |
Print
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pubmed:day |
18
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pubmed:volume |
277
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
39561-5
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:12177004-Animals,
pubmed-meshheading:12177004-Anticholesteremic Agents,
pubmed-meshheading:12177004-Blotting, Western,
pubmed-meshheading:12177004-Carrier Proteins,
pubmed-meshheading:12177004-Cholesterol,
pubmed-meshheading:12177004-Cholesterol, HDL,
pubmed-meshheading:12177004-DNA-Binding Proteins,
pubmed-meshheading:12177004-Dose-Response Relationship, Drug,
pubmed-meshheading:12177004-Gene Expression Regulation,
pubmed-meshheading:12177004-Hydrocarbons, Fluorinated,
pubmed-meshheading:12177004-Ligands,
pubmed-meshheading:12177004-Lipid Metabolism,
pubmed-meshheading:12177004-Lipoproteins, HDL,
pubmed-meshheading:12177004-Liver,
pubmed-meshheading:12177004-Macrophages,
pubmed-meshheading:12177004-Membrane Proteins,
pubmed-meshheading:12177004-Mice,
pubmed-meshheading:12177004-Mice, Inbred C57BL,
pubmed-meshheading:12177004-Orphan Nuclear Receptors,
pubmed-meshheading:12177004-Phospholipid Transfer Proteins,
pubmed-meshheading:12177004-Phospholipids,
pubmed-meshheading:12177004-RNA, Messenger,
pubmed-meshheading:12177004-Receptors, Cytoplasmic and Nuclear,
pubmed-meshheading:12177004-Receptors, Retinoic Acid,
pubmed-meshheading:12177004-Receptors, Thyroid Hormone,
pubmed-meshheading:12177004-Sulfonamides,
pubmed-meshheading:12177004-Time Factors,
pubmed-meshheading:12177004-Transcription, Genetic
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pubmed:year |
2002
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pubmed:articleTitle |
Phospholipid transfer protein is regulated by liver X receptors in vivo.
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pubmed:affiliation |
Lilly Research Laboratories, Eli Lilly & Company, Indianapolis, Indiana 46285, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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