|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
4
|
|
pubmed:dateCreated |
2002-8-7
|
|
pubmed:abstractText |
The central role for Th2 cells in the development of Ag-induced airway hyperresponsiveness and eosinophilic inflammation is well documented. We have reported a crucial role for TCR-induced activation of the Ras/extracellular signal-regulated kinase mitogen-activated protein kinase cascade in Th2 cell differentiation. Here, we show that the development of both OVA-induced airway hyperresponsiveness and eosinophilic airway inflammation in a mouse asthma model are attenuated in transgenic mice by the overexpression of enzymatically inactive Ras molecules in T cells. In addition, reduced levels of IL-5 production and eosinophilic inflammation induced by nematode infection (Nippostrongylus brasiliensis or Heligmosomoides polygyrus) were detected. Thus, the level of Ras activation in T cells appears to determine Th2-dependent eosinophilic inflammation and Ag-induced airway hyperresponsiveness.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Aug
|
|
pubmed:issn |
0022-1767
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
15
|
|
pubmed:volume |
169
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
2134-40
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:12165542-Animals,
pubmed-meshheading:12165542-Asthma,
pubmed-meshheading:12165542-Bronchial Hyperreactivity,
pubmed-meshheading:12165542-Disease Models, Animal,
pubmed-meshheading:12165542-Eosinophilia,
pubmed-meshheading:12165542-Gene Expression Regulation,
pubmed-meshheading:12165542-Genes, ras,
pubmed-meshheading:12165542-Inflammation,
pubmed-meshheading:12165542-Interleukin-5,
pubmed-meshheading:12165542-Mice,
pubmed-meshheading:12165542-Mice, Inbred BALB C,
pubmed-meshheading:12165542-Mice, Inbred C57BL,
pubmed-meshheading:12165542-Mice, Transgenic,
pubmed-meshheading:12165542-Nematospiroides dubius,
pubmed-meshheading:12165542-Nippostrongylus,
pubmed-meshheading:12165542-Ovalbumin,
pubmed-meshheading:12165542-Strongylida Infections,
pubmed-meshheading:12165542-T-Lymphocytes,
pubmed-meshheading:12165542-Th2 Cells
|
|
pubmed:year |
2002
|
|
pubmed:articleTitle |
Ras activation in T cells determines the development of antigen-induced airway hyperresponsiveness and eosinophilic inflammation.
|
|
pubmed:affiliation |
Department of Molecular Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
