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| pubmed-article:12165484 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:12165484 | pubmed:dateCreated | 2002-8-7 | lld:pubmed |
| pubmed-article:12165484 | pubmed:abstractText | IFN-alphabeta is a potent immunoregulatory cytokine involved in the defense against viral and bacterial infections. In this study, we describe an as yet undefined IFN-alphabeta-dependent pathway of IFN-gamma induction in mice. This pathway is based on a synergism of IFN-alphabeta and IL-18, and is independent of IL-12 signaling yet dependent on STAT4. In contradiction to current dogma, we show further that IFN-alphabeta alone induces tyrosine phosphorylation of STAT4 in murine splenocytes of different mouse strains. This pathway participates in the induction of IFN-gamma by Gram-negative bacteria and is therefore expected to play a role whenever IFN-alpha or IFN-beta and IL-18 are produced concomitantly during bacterial, viral, or other infections. | lld:pubmed |
| pubmed-article:12165484 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12165484 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12165484 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:12165484 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12165484 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:12165484 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:12165484 | pubmed:author | pubmed-author:GalanosChrisC | lld:pubmed |
| pubmed-article:12165484 | pubmed:author | pubmed-author:MerlinThomasT | lld:pubmed |
| pubmed-article:12165484 | pubmed:author | pubmed-author:ChvatchkoYola... | lld:pubmed |
| pubmed-article:12165484 | pubmed:author | pubmed-author:FreudenbergMa... | lld:pubmed |
| pubmed-article:12165484 | pubmed:author | pubmed-author:KalisChristop... | lld:pubmed |
| pubmed-article:12165484 | pubmed:author | pubmed-author:StübigHellaH | lld:pubmed |
| pubmed-article:12165484 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12165484 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:12165484 | pubmed:volume | 169 | lld:pubmed |
| pubmed-article:12165484 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12165484 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12165484 | pubmed:pagination | 1665-8 | lld:pubmed |
| pubmed-article:12165484 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:12165484 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12165484 | pubmed:articleTitle | Cutting edge: a murine, IL-12-independent pathway of IFN-gamma induction by gram-negative bacteria based on STAT4 activation by Type I IFN and IL-18 signaling. | lld:pubmed |
| pubmed-article:12165484 | pubmed:affiliation | Max-Planck-Institut für Immunbiologie, Freiburg, Germany. freudenberg@immunbio.mpg.de | lld:pubmed |
| pubmed-article:12165484 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12165484 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:12165484 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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