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rdf:type |
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lifeskim:mentions |
umls-concept:C0018150,
umls-concept:C0021747,
umls-concept:C0037083,
umls-concept:C0152060,
umls-concept:C0205154,
umls-concept:C0205263,
umls-concept:C0332307,
umls-concept:C0383327,
umls-concept:C0591833,
umls-concept:C1306235,
umls-concept:C1335874,
umls-concept:C1415900,
umls-concept:C1527178,
umls-concept:C1704259,
umls-concept:C1705938,
umls-concept:C1705987,
umls-concept:C1710082,
umls-concept:C1879547
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pubmed:issue |
4
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pubmed:dateCreated |
2002-8-7
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pubmed:abstractText |
IFN-alphabeta is a potent immunoregulatory cytokine involved in the defense against viral and bacterial infections. In this study, we describe an as yet undefined IFN-alphabeta-dependent pathway of IFN-gamma induction in mice. This pathway is based on a synergism of IFN-alphabeta and IL-18, and is independent of IL-12 signaling yet dependent on STAT4. In contradiction to current dogma, we show further that IFN-alphabeta alone induces tyrosine phosphorylation of STAT4 in murine splenocytes of different mouse strains. This pathway participates in the induction of IFN-gamma by Gram-negative bacteria and is therefore expected to play a role whenever IFN-alpha or IFN-beta and IL-18 are produced concomitantly during bacterial, viral, or other infections.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-alpha,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-beta,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-12,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-18,
http://linkedlifedata.com/resource/pubmed/chemical/STAT4 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Stat4 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/Tyrosine
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0022-1767
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
169
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1665-8
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:12165484-Animals,
pubmed-meshheading:12165484-DNA-Binding Proteins,
pubmed-meshheading:12165484-Gram-Negative Bacteria,
pubmed-meshheading:12165484-Interferon-alpha,
pubmed-meshheading:12165484-Interferon-beta,
pubmed-meshheading:12165484-Interferon-gamma,
pubmed-meshheading:12165484-Interleukin-12,
pubmed-meshheading:12165484-Interleukin-18,
pubmed-meshheading:12165484-Mice,
pubmed-meshheading:12165484-Mice, Inbred BALB C,
pubmed-meshheading:12165484-Mice, Inbred C57BL,
pubmed-meshheading:12165484-Mice, Knockout,
pubmed-meshheading:12165484-Phosphorylation,
pubmed-meshheading:12165484-STAT4 Transcription Factor,
pubmed-meshheading:12165484-Signal Transduction,
pubmed-meshheading:12165484-Spleen,
pubmed-meshheading:12165484-Trans-Activators,
pubmed-meshheading:12165484-Tyrosine
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pubmed:year |
2002
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pubmed:articleTitle |
Cutting edge: a murine, IL-12-independent pathway of IFN-gamma induction by gram-negative bacteria based on STAT4 activation by Type I IFN and IL-18 signaling.
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pubmed:affiliation |
Max-Planck-Institut für Immunbiologie, Freiburg, Germany. freudenberg@immunbio.mpg.de
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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