| pubmed-article:12165397 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12165397 | lifeskim:mentions | umls-concept:C0028040 | lld:lifeskim |
| pubmed-article:12165397 | lifeskim:mentions | umls-concept:C0001554 | lld:lifeskim |
| pubmed-article:12165397 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:12165397 | lifeskim:mentions | umls-concept:C0205095 | lld:lifeskim |
| pubmed-article:12165397 | lifeskim:mentions | umls-concept:C0549183 | lld:lifeskim |
| pubmed-article:12165397 | lifeskim:mentions | umls-concept:C0504074 | lld:lifeskim |
| pubmed-article:12165397 | lifeskim:mentions | umls-concept:C0001962 | lld:lifeskim |
| pubmed-article:12165397 | lifeskim:mentions | umls-concept:C0041252 | lld:lifeskim |
| pubmed-article:12165397 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:12165397 | lifeskim:mentions | umls-concept:C1154450 | lld:lifeskim |
| pubmed-article:12165397 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:12165397 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:12165397 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:12165397 | pubmed:dateCreated | 2002-8-7 | lld:pubmed |
| pubmed-article:12165397 | pubmed:abstractText | Serotonin (5-hydroxytryptamine, 5-HT) has been implicated in the pathophysiology of various neuropsychiatric disorders. In the present study, the effects of alcohol and nicotine on the synthesis of 5-HT and the expression of tryptophan hydroxylase (TPH), the rate-limiting enzyme of 5-HT synthesis, in the dorsal and median raphe of young rats were investigated via immunohistochemistry. The numbers of the 5-HT-positive and TPH-positive cells were reduced by alcohol and nicotine treatment in a dose-dependent manner. Based on the results, it can be suggested that the pathogenesis of alcohol- and nicotine-induced neuropsychological disorders involves alcohol- and nicotine-induced suppression of 5-HT synthesis and TPH expression in raphe, and that this may be of particular relevance in the consumption of alcohol and nicotine during adolescence. | lld:pubmed |
| pubmed-article:12165397 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12165397 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12165397 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12165397 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12165397 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12165397 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12165397 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12165397 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12165397 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12165397 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12165397 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:12165397 | pubmed:issn | 0304-3940 | lld:pubmed |
| pubmed-article:12165397 | pubmed:author | pubmed-author:KimHongH | lld:pubmed |
| pubmed-article:12165397 | pubmed:author | pubmed-author:KimEe-HwaEH | lld:pubmed |
| pubmed-article:12165397 | pubmed:author | pubmed-author:ShinDong-Hoon... | lld:pubmed |
| pubmed-article:12165397 | pubmed:author | pubmed-author:KimChang-JuCJ | lld:pubmed |
| pubmed-article:12165397 | pubmed:author | pubmed-author:JangMi-HyeonM... | lld:pubmed |
| pubmed-article:12165397 | pubmed:author | pubmed-author:ShinMin-ChulM... | lld:pubmed |
| pubmed-article:12165397 | pubmed:author | pubmed-author:JungSae-BinSB | lld:pubmed |
| pubmed-article:12165397 | pubmed:author | pubmed-author:KimYoung-PyoY... | lld:pubmed |
| pubmed-article:12165397 | pubmed:author | pubmed-author:KimSung-SooSS | lld:pubmed |
| pubmed-article:12165397 | pubmed:author | pubmed-author:LeeTaeck-Hyun... | lld:pubmed |
| pubmed-article:12165397 | pubmed:copyrightInfo | Copyright 2002 Elsevier Science Ireland Ltd. | lld:pubmed |
| pubmed-article:12165397 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12165397 | pubmed:day | 30 | lld:pubmed |
| pubmed-article:12165397 | pubmed:volume | 329 | lld:pubmed |
| pubmed-article:12165397 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12165397 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12165397 | pubmed:pagination | 141-4 | lld:pubmed |
| pubmed-article:12165397 | pubmed:dateRevised | 2003-11-14 | lld:pubmed |
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| pubmed-article:12165397 | pubmed:meshHeading | pubmed-meshheading:12165397... | lld:pubmed |
| pubmed-article:12165397 | pubmed:meshHeading | pubmed-meshheading:12165397... | lld:pubmed |
| pubmed-article:12165397 | pubmed:meshHeading | pubmed-meshheading:12165397... | lld:pubmed |
| pubmed-article:12165397 | pubmed:meshHeading | pubmed-meshheading:12165397... | lld:pubmed |
| pubmed-article:12165397 | pubmed:meshHeading | pubmed-meshheading:12165397... | lld:pubmed |
| pubmed-article:12165397 | pubmed:meshHeading | pubmed-meshheading:12165397... | lld:pubmed |
| pubmed-article:12165397 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12165397 | pubmed:articleTitle | Alcohol and nicotine administration inhibits serotonin synthesis and tryptophan hydroxylase expression in dorsal and median raphe of young rats. | lld:pubmed |
| pubmed-article:12165397 | pubmed:affiliation | Department of Physiology, College of Medicine, Kyung Hee University, #1 Hoigi-dong, Dongdaemoon-gu, Seoul 130-701, South Korea. | lld:pubmed |
| pubmed-article:12165397 | pubmed:publicationType | Journal Article | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12165397 | lld:pubmed |
