Source:http://linkedlifedata.com/resource/pubmed/id/12161548
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8
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| pubmed:dateCreated |
2002-8-5
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| pubmed:abstractText |
The Pro12Ala polymorphism of PPAR-gamma 2 has been shown to influence insulin sensitivity and the risk of type 2 diabetes in various ethnic populations. We examined whether the polymorphism was related to the insulin resistance syndrome (IRS) among nondiabetic Danish subjects. The Pro12Ala variant was examined using PCR-restriction fragment length polymorphism in a phenotypically well characterized population-based sample of 2245 nondiabetic subjects. The study participants were characterized by a number of anthropometric and biochemical measurements and the European Group for the Study of Insulin Resistance criteria enabling a classification of the study population in an IRS group and a non-IRS group. The allelic frequency of the Pro12Ala polymorphism in the total study sample was 14% (95% confidence interval, 13-15%). Two hundred ninety-four subjects fulfilled the European Group for the Study of Insulin Resistance criteria defining the IRS. The frequency of the Ala allele was 12.6% in the IRS group and 14.2% among subjects classified as not having the IRS (P = 0.15). However, the frequency of the variant in the homozygous form was significantly lower in the IRS group [0.7% (0-1.6%)] compared with the frequency in the non-IRS group [2.8% (2.1-3.5%); P = 0.02; odds ratio, 0.24 (0.06-0.99)]. Moreover, in the total study population, homozygous carriers of the variant had lower levels of fasting serum triglyceride [1.1 +/- 0.4 mmol/liter (means +/- SD) vs. 1.4 +/- 0.9 mmol/liter; P = 0.04] and a lower diastolic blood pressure (79 +/- 8 mm Hg vs. 82 +/- 11 mm Hg; P = 0.01) compared with wild-type carriers. The same tendency was observed with regard to the homeostasis model assessment estimate of insulin resistance (P = 0.16). There were no differences between genotype groups with respect to measures of body composition (BMI and waist circumference). In conclusion, homozygosity of the codon 12 variant of PPAR-gamma 2 confers a reduced risk of the IRS among Danish Caucasian subjects.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Aug
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| pubmed:issn |
0021-972X
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
87
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
3989-92
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:12161548-Adult,
pubmed-meshheading:12161548-Aged,
pubmed-meshheading:12161548-Alanine,
pubmed-meshheading:12161548-Cohort Studies,
pubmed-meshheading:12161548-Denmark,
pubmed-meshheading:12161548-Disease Susceptibility,
pubmed-meshheading:12161548-Female,
pubmed-meshheading:12161548-Gene Frequency,
pubmed-meshheading:12161548-Genetic Predisposition to Disease,
pubmed-meshheading:12161548-Homozygote,
pubmed-meshheading:12161548-Humans,
pubmed-meshheading:12161548-Male,
pubmed-meshheading:12161548-Metabolic Syndrome X,
pubmed-meshheading:12161548-Middle Aged,
pubmed-meshheading:12161548-Phenotype,
pubmed-meshheading:12161548-Polymorphism, Single Nucleotide,
pubmed-meshheading:12161548-Proline,
pubmed-meshheading:12161548-Receptors, Cytoplasmic and Nuclear,
pubmed-meshheading:12161548-Risk Factors,
pubmed-meshheading:12161548-Transcription Factors
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| pubmed:year |
2002
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| pubmed:articleTitle |
Comment: studies of the Pro12Ala polymorphism of the PPAR-gamma gene in the Danish MONICA cohort: homozygosity of the Ala allele confers a decreased risk of the insulin resistance syndrome.
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| pubmed:affiliation |
Department of Endocrinology (L.F., K.B., S.M., S.A.U.) and Clinical Biochemistry (M.F.), Hvidovre University Hospital, Hvidovre DK-2650, Denmark.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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