|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
17
|
|
pubmed:dateCreated |
2002-8-5
|
|
pubmed:abstractText |
A series of substituted N-(3,5-dichlorobenzenesulfonyl)-(L)-prolyl- and (L)-azetidyl-beta-biaryl beta-alanine derivatives was prepared as selective and potent VLA-4 antagonists. The 2,6-dioxygenated biaryl substitution pattern is important for optimizing potency. Oral bioavailability was variable and may be a result of binding to circulating plasma proteins.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Sep
|
|
pubmed:issn |
0960-894X
|
|
pubmed:author |
pubmed-author:CollettiAdriaA,
pubmed-author:DeLaszloStephen ESE,
pubmed-author:EggerLinda ALA,
pubmed-author:HagmannWilliam KWK,
pubmed-author:KidambiUshaU,
pubmed-author:KopkaIhor EIE,
pubmed-author:LanzaThomasTJr,
pubmed-author:LevorseDorothyD,
pubmed-author:LinLinus SLS,
pubmed-author:LyonsKathrynK,
pubmed-author:MacCossMalcolmM,
pubmed-author:MagriotisPlato APA,
pubmed-author:McCauleyErmengildaE,
pubmed-author:MillsSander GSG,
pubmed-author:MumfordRichard ARA,
pubmed-author:OwensKarenK,
pubmed-author:SchmidtJohn AJA,
pubmed-author:StearnsRalphR,
pubmed-author:TefferaYohannesY,
pubmed-author:TongSharonS,
pubmed-author:Van RiperGailG,
pubmed-author:VincentStellaS,
pubmed-author:YoungDavidD
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
2
|
|
pubmed:volume |
12
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
2415-8
|
|
pubmed:dateRevised |
2004-11-17
|
|
pubmed:meshHeading |
pubmed-meshheading:12161146-Administration, Oral,
pubmed-meshheading:12161146-Alanine,
pubmed-meshheading:12161146-Biological Availability,
pubmed-meshheading:12161146-Humans,
pubmed-meshheading:12161146-Inhibitory Concentration 50,
pubmed-meshheading:12161146-Integrin alpha4beta1,
pubmed-meshheading:12161146-Jurkat Cells,
pubmed-meshheading:12161146-Metabolic Clearance Rate,
pubmed-meshheading:12161146-Propionic Acids,
pubmed-meshheading:12161146-Protein Binding,
pubmed-meshheading:12161146-Structure-Activity Relationship,
pubmed-meshheading:12161146-Vascular Cell Adhesion Molecule-1
|
|
pubmed:year |
2002
|
|
pubmed:articleTitle |
Substituted 3-amino biaryl propionic acids as potent VLA-4 antagonists.
|
|
pubmed:affiliation |
Department of Medicinal Chemistry, Merck Research Laboratories, Rahway, NJ 07065, USA. ihor_kopka@merck.com
|
|
pubmed:publicationType |
Journal Article
|
