Linked Life Data

12160260

Source:http://linkedlifedata.com/resource/pubmed/id/12160260

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2002-8-5
pubmed:abstractText
One of the most common deficits observed during late adulthood is a loss in the ability to learn and remember new information. This cognitive ability depends mainly on the integrity of the hippocampal formation and the prefrontal cortex, which are especially susceptible to the effects of age. Here we provide a selective review of the literature gathered from studies carried out in humans and animals, examining the effect of aging on the functional anatomy of memory. We discuss some of the methodological and theoretical difficulties associated with the current approach to the study of aging and, in turn, a series of strategies that may be implemented to ensure the most accurate interpretation of the data. Altogether, the evidence discussed in this review supports the idea that there is no general age-related deterioration of the neural substrates of memory, but rather a differential effect in which some brain areas may be adversely affected while others may compensate for the neurobiological deterioration associated with age.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0334-1763
pubmed:author
pubmed:issnType
Print
pubmed:volume
13
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
167-81
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
Dissecting the effect of aging on the neural substrates of memory: deterioration, preservation or functional reorganization?
pubmed:affiliation
Rotman Research Institute of Baycrest Centre, Department of Psychology, University of Toronto, Ontario, Canada. valeria@psych.utoronto.ca
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't