Linked Life Data

12145034

Source:http://linkedlifedata.com/resource/pubmed/id/12145034

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2002-7-29
pubmed:abstractText
Hepatic sinusoidal endothelial cells (SECs) are more vulnerable to hypoxia or hypothermia than hepatocytes. To test the hypothesis that hepatic venous desaturation during cardiopulmonary bypass (CPB) leads to impairment of SEC function, we studied the plasma kinetics of endogenous hyaluronate (HA), a sensitive indicator of SEC function, and hepatosplanchnic oxygenation during and after CPB. Twenty-five consecutive patients scheduled for elective coronary artery bypass graft surgery, who underwent normothermic (>35 degrees C; n = 15) or mild hypothermic (32 degrees C; n = 10) CPB participated in this study. A hepatic venous catheter was inserted into each patient to monitor hepatosplanchnic oxygenation and serum levels of HA concentration. Hepatic venous oxygen saturation decreased essentially to a similar degree during normothermic and mild hypothermic CPB. Hepatosplanchnic oxygen consumption and extraction increased during normothermic (P < 0.05), but not mild hypothermic, CPB. Both arterial and hepatic venous HA concentrations showed threefold increases during and after CPB in both groups. A positive correlation was found between hepatosplanchnic oxygen consumption and arterial HA concentrations during CPB, suggesting a role of changes in hepatosplanchnic oxygen metabolism in the mechanisms of increases in serum HA concentrations. The failure of the liver to increase HA extraction to a great degree suggests that a functional impairment of the SEC may contribute to the observed increase of serum HA. IMPLICATIONS: Hepatic sinusoidal endothelial cells (SECs) are pivotal in the regulation of sinusoidal blood flow. This study showed that SEC function might be impaired during and after cardiopulmonary bypass, irrespective of the temperature management.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0003-2999
pubmed:author
pubmed:issnType
Print
pubmed:volume
95
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
278-86, table of contents
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:12145034-Aged, pubmed-meshheading:12145034-Anesthesia, pubmed-meshheading:12145034-Blood Gas Analysis, pubmed-meshheading:12145034-Blood Glucose, pubmed-meshheading:12145034-Body Temperature, pubmed-meshheading:12145034-Cardiopulmonary Bypass, pubmed-meshheading:12145034-Cerebral Infarction, pubmed-meshheading:12145034-Coloring Agents, pubmed-meshheading:12145034-Endothelium, Vascular, pubmed-meshheading:12145034-Female, pubmed-meshheading:12145034-Hemodynamics, pubmed-meshheading:12145034-Hepatocytes, pubmed-meshheading:12145034-Humans, pubmed-meshheading:12145034-Hyaluronic Acid, pubmed-meshheading:12145034-Hypothermia, Induced, pubmed-meshheading:12145034-Indocyanine Green, pubmed-meshheading:12145034-Lactic Acid, pubmed-meshheading:12145034-Liver Circulation, pubmed-meshheading:12145034-Liver Function Tests, pubmed-meshheading:12145034-Male, pubmed-meshheading:12145034-Middle Aged, pubmed-meshheading:12145034-Myocardial Infarction, pubmed-meshheading:12145034-Oxygen, pubmed-meshheading:12145034-Splanchnic Circulation
pubmed:year
2002
pubmed:articleTitle
Impairment of hepatosplanchnic oxygenation and increase of serum hyaluronate during normothermic and mild hypothermic cardiopulmonary bypass.
pubmed:affiliation
Department of Anesthesiology, Saitama Cardiovascular and Pulmonary Center, Saitama, Japan. richard@ka2.so-net.ne.jp
pubmed:publicationType
Journal Article, Clinical Trial, Research Support, Non-U.S. Gov't