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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2002-7-19
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pubmed:abstractText |
The main autoantigen recognized by the sera of patients with coeliac disease (CD) is tissue transglutaminase (tTG). A human-recombinant form of tTG was used to develop an ELISA to measure anti-tTG serum antibodies for the diagnosis of CD. Preliminary retrospective reports suggest that the human tTG-based ELISA could identify coeliac patients missed by the IgA-anti-endomysium antibody test (AEA). Whether the human recombinant tTG ELISA is sufficiently accurate to become the main diagnostic CD tool in everyday clinical practice is unknown. The objective was to determine, in a prospective study, the sensitivity and specificity of an ELISA test based on the use of human tTG compared with AEA, to analyse the discordant cases for HLA DQ2-8 and for clinical and intestinal biopsy characteristics.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0036-5521
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pubmed:author |
pubmed-author:AmorosoAA,
pubmed-author:BaldasVV,
pubmed-author:BerteMM,
pubmed-author:BradburyAA,
pubmed-author:CrovellaSS,
pubmed-author:KES JSJ,
pubmed-author:MartelossiSS,
pubmed-author:MarzariRR,
pubmed-author:SantosOO,
pubmed-author:SblatteroDD,
pubmed-author:SpanòAA,
pubmed-author:TommasiniAA,
pubmed-author:TorreGG,
pubmed-author:TrevisiolCC,
pubmed-author:VenturaAA
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pubmed:issnType |
Print
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pubmed:volume |
37
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
679-84
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12126246-Adolescent,
pubmed-meshheading:12126246-Adult,
pubmed-meshheading:12126246-Aged,
pubmed-meshheading:12126246-Ambulatory Care Facilities,
pubmed-meshheading:12126246-Autoantibodies,
pubmed-meshheading:12126246-Biopsy, Needle,
pubmed-meshheading:12126246-Case-Control Studies,
pubmed-meshheading:12126246-Celiac Disease,
pubmed-meshheading:12126246-Child,
pubmed-meshheading:12126246-Child, Preschool,
pubmed-meshheading:12126246-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:12126246-Female,
pubmed-meshheading:12126246-Gastric Mucosa,
pubmed-meshheading:12126246-HLA-DQ Antigens,
pubmed-meshheading:12126246-Humans,
pubmed-meshheading:12126246-Infant,
pubmed-meshheading:12126246-Infant, Newborn,
pubmed-meshheading:12126246-Male,
pubmed-meshheading:12126246-Mass Screening,
pubmed-meshheading:12126246-Middle Aged,
pubmed-meshheading:12126246-Probability,
pubmed-meshheading:12126246-Prospective Studies,
pubmed-meshheading:12126246-Reference Values,
pubmed-meshheading:12126246-Reproducibility of Results,
pubmed-meshheading:12126246-Sensitivity and Specificity,
pubmed-meshheading:12126246-Statistics, Nonparametric,
pubmed-meshheading:12126246-Transglutaminases
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pubmed:year |
2002
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pubmed:articleTitle |
A reliable screening procedure for coeliac disease in clinical practice.
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pubmed:affiliation |
Dept of Reproductive and Development Science, IRCCS Burlo Garofolo, University of Trieste, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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