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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2002-7-18
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pubmed:abstractText |
Fibroblast growth factor 14 (FGF14) belongs to a distinct subclass of FGFs that is expressed in the developing and adult CNS. We disrupted the Fgf14 gene and introduced an Fgf14(N-beta-Gal) allele that abolished Fgf14 expression and generated a fusion protein (FGF14N-beta-gal) containing the first exon of FGF14 and beta-galactosidase. Fgf14-deficient mice were viable, fertile, and anatomically normal, but developed ataxia and a paroxysmal hyperkinetic movement disorder. Neuropharmacological studies showed that Fgf14-deficient mice have reduced responses to dopamine agonists. The paroxysmal hyperkinetic movement disorder phenocopies a form of dystonia, a disease often associated with dysfunction of the putamen. Strikingly, the FGF14N-beta-gal chimeric protein was efficiently transported into neuronal processes in the basal ganglia and cerebellum. Together, these studies identify a novel function for FGF14 in neuronal signaling and implicate FGF14 in axonal trafficking and synaptosomal function.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0896-6273
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pubmed:author |
pubmed-author:BardgettMark EME,
pubmed-author:LouJunyangJ,
pubmed-author:McNeilBenjamin DBD,
pubmed-author:NardiAnthonyA,
pubmed-author:OrnitzDavid MDM,
pubmed-author:ReidDavid CDC,
pubmed-author:WangQingQ,
pubmed-author:WongMichaelM,
pubmed-author:WozniakDavid FDF,
pubmed-author:XXX,
pubmed-author:YamadaKelvinK
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pubmed:issnType |
Print
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pubmed:day |
3
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pubmed:volume |
35
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
25-38
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:12123606-Animals,
pubmed-meshheading:12123606-Ataxia,
pubmed-meshheading:12123606-Axonal Transport,
pubmed-meshheading:12123606-Axons,
pubmed-meshheading:12123606-Basal Ganglia,
pubmed-meshheading:12123606-Brain,
pubmed-meshheading:12123606-Cell Movement,
pubmed-meshheading:12123606-Cerebellum,
pubmed-meshheading:12123606-Chorea,
pubmed-meshheading:12123606-Cocaine,
pubmed-meshheading:12123606-Dopamine Agonists,
pubmed-meshheading:12123606-Female,
pubmed-meshheading:12123606-Fibroblast Growth Factors,
pubmed-meshheading:12123606-Gene Targeting,
pubmed-meshheading:12123606-Male,
pubmed-meshheading:12123606-Mice,
pubmed-meshheading:12123606-Mice, Knockout,
pubmed-meshheading:12123606-Mitogen-Activated Protein Kinases,
pubmed-meshheading:12123606-Neostriatum,
pubmed-meshheading:12123606-Proto-Oncogene Proteins c-fos,
pubmed-meshheading:12123606-Substantia Nigra,
pubmed-meshheading:12123606-beta-Galactosidase
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pubmed:year |
2002
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pubmed:articleTitle |
Ataxia and paroxysmal dyskinesia in mice lacking axonally transported FGF14.
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pubmed:affiliation |
Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St. Louis 63110, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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