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pubmed-article:12123595pubmed:abstractTextP-Rex1, a novel Rac activator, has been identified in the first biochemical purification of a guanine nucleotide exchange factor for GTPases of the Rho family. P-Rex1 is synergistically activated by PIP(3) and Gbetagamma and may act as a coincidence detector for these signaling molecules.lld:pubmed
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pubmed-article:12123595pubmed:articleTitleRac activation: P-Rex1 - a convergence point for PIP(3) and Gbetagamma?lld:pubmed
pubmed-article:12123595pubmed:affiliationDepartment of Cell Biology, Harvard Medical School, 240 Longwood Ave/ C-1, 502, Boston, Massachusetts 02115, USA. orion_weiner@hms.harvard.edulld:pubmed
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