12123595

Source:http://linkedlifedata.com/resource/pubmed/id/12123595

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0279391, umls-concept:C0443193, umls-concept:C1418587, umls-concept:C1552961, umls-concept:C1847163, umls-concept:C1879547
pubmed:issue	12
pubmed:dateCreated	2002-7-18
pubmed:abstractText	P-Rex1, a novel Rac activator, has been identified in the first biochemical purification of a guanine nucleotide exchange factor for GTPases of the Rho family. P-Rex1 is synergistically activated by PIP(3) and Gbetagamma and may act as a coincidence detector for these signaling molecules.
pubmed:grant	http://linkedlifedata.com/resource/pubmed/grant/R01 GM027800-27
pubmed:commentsCorrections	http://linkedlifedata.com/resource/pubmed/commentcorrection/12123595-10072071, http://linkedlifedata.com/resource/pubmed/commentcorrection/12123595-10220378, http://linkedlifedata.com/resource/pubmed/commentcorrection/12123595-10224076, http://linkedlifedata.com/resource/pubmed/commentcorrection/12123595-10364257, http://linkedlifedata.com/resource/pubmed/commentcorrection/12123595-10419906, http://linkedlifedata.com/resource/pubmed/commentcorrection/12123595-10523848, http://linkedlifedata.com/resource/pubmed/commentcorrection/12123595-11230144, http://linkedlifedata.com/resource/pubmed/commentcorrection/12123595-11230698, http://linkedlifedata.com/resource/pubmed/commentcorrection/12123595-11248547, http://linkedlifedata.com/resource/pubmed/commentcorrection/12123595-11672526, http://linkedlifedata.com/resource/pubmed/commentcorrection/12123595-11879201, http://linkedlifedata.com/resource/pubmed/commentcorrection/12123595-11891119, http://linkedlifedata.com/resource/pubmed/commentcorrection/12123595-11907569, http://linkedlifedata.com/resource/pubmed/commentcorrection/12123595-7627555, http://linkedlifedata.com/resource/pubmed/commentcorrection/12123595-8752216, http://linkedlifedata.com/resource/pubmed/commentcorrection/12123595-9013670, http://linkedlifedata.com/resource/pubmed/commentcorrection/12123595-9094719, http://linkedlifedata.com/resource/pubmed/commentcorrection/12123595-9438848
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/9107782
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Guanine Nucleotide Exchange Factors, http://linkedlifedata.com/resource/pubmed/chemical/Heterotrimeric GTP-Binding Proteins, http://linkedlifedata.com/resource/pubmed/chemical/PREX1 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Phosphatidylinositol 3-Kinases, http://linkedlifedata.com/resource/pubmed/chemical/Phosphatidylinositol Phosphates, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Platelet-Derived Growth..., http://linkedlifedata.com/resource/pubmed/chemical/phosphatidylinositol..., http://linkedlifedata.com/resource/pubmed/chemical/rac GTP-Binding Proteins
pubmed:status	MEDLINE
pubmed:month	Jun
pubmed:issn	0960-9822
pubmed:author	pubmed-author:WeinerOrion DOD
pubmed:issnType	Print
pubmed:day	25
pubmed:volume	12
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	R429-31
pubmed:dateRevised	2010-11-18
pubmed:meshHeading	pubmed-meshheading:12123595-Enzyme Activation, pubmed-meshheading:12123595-Guanine Nucleotide Exchange Factors, pubmed-meshheading:12123595-Heterotrimeric GTP-Binding Proteins, pubmed-meshheading:12123595-Humans, pubmed-meshheading:12123595-Neutrophils, pubmed-meshheading:12123595-Phosphatidylinositol 3-Kinases, pubmed-meshheading:12123595-Phosphatidylinositol Phosphates, pubmed-meshheading:12123595-Receptors, Platelet-Derived Growth Factor, pubmed-meshheading:12123595-rac GTP-Binding Proteins
pubmed:year	2002
pubmed:articleTitle	Rac activation: P-Rex1 - a convergence point for PIP(3) and Gbetagamma?
pubmed:affiliation	Department of Cell Biology, Harvard Medical School, 240 Longwood Ave/ C-1, 502, Boston, Massachusetts 02115, USA. orion_weiner@hms.harvard.edu
pubmed:publicationType	Journal Article