Linked Life Data

12122032

Source:http://linkedlifedata.com/resource/pubmed/id/12122032

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2002-7-17
pubmed:abstractText
The present study was designed to investigate the time-course of neural activity underlying the disruption of response monitoring in patients with schizophrenia. Event-related brain potentials were recorded from 12 patients with schizophrenia and from 12 age-matched controls while they performed a computerized version of the Stroop color-naming task. In control participants, but not in patients with schizophrenia, intrusion errors elicited an error-related negativity (ERN) that peaked at approximately 40 ms after the response and was maximum over the central region of the scalp. Brain electrical source analysis revealed an anterior cingulate generator for the ERN. Patients also showed reduced error-related slowing of response time following intrusion errors. These findings provide neuro-physiological evidence indicating that deficits in error monitoring in schizophrenia arise from a disruption of error-detection processes, possibly attributable to anterior cingulate dysfunction.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1047-3211
pubmed:author
pubmed:issnType
Print
pubmed:volume
12
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
840-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
Neurophysiological evidence of error-monitoring deficits in patients with schizophrenia.
pubmed:affiliation
Rotman Research Institute of Baycrest Centre for Geriatric Care, Department of Psychology, University of Toronto, 3560 Bathurst Street, Toronto, Ontario, Canada M6A 2E1. calain@rotman-baycrest.on.ca
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't