Source:http://linkedlifedata.com/resource/pubmed/id/12121509
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
7
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pubmed:dateCreated |
2002-7-17
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pubmed:abstractText |
Activation of hepatic stellate cells (HSC) results in the transdifferentiation of the resting (quiescent) phenotype to one characterized by loss of vitamin A droplets, increased alpha-smooth muscle actin (SMA) expression and increased collagen production. Aldehydic products of lipid peroxidation have been shown to increase collagen production by cultured fibroblasts and by passaged HSC, but it is unclear whether these products of lipid peroxidation can initiate the activation of HSC. In the present study the effects were examined of two aldehydic products of lipid peroxidation, malondialdehyde (MDA) and 4-hydroxynonenal (HNE), on activation of rat HSC in early culture as measured by SMA and desmin expression, and collagen production.
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pubmed:grant | |
pubmed:commentsCorrections | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Actins,
http://linkedlifedata.com/resource/pubmed/chemical/Aldehydes,
http://linkedlifedata.com/resource/pubmed/chemical/Collagen,
http://linkedlifedata.com/resource/pubmed/chemical/Desmin,
http://linkedlifedata.com/resource/pubmed/chemical/Malondialdehyde,
http://linkedlifedata.com/resource/pubmed/chemical/tert-4-hydroxy-2-nonenal
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0815-9319
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pubmed:author | |
pubmed:copyrightInfo |
Copyright 2002 Blackwell Publishing Asia Pty Ltd
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pubmed:issnType |
Print
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pubmed:volume |
17
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
785-90
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:12121509-Actins,
pubmed-meshheading:12121509-Aldehydes,
pubmed-meshheading:12121509-Animals,
pubmed-meshheading:12121509-Blotting, Western,
pubmed-meshheading:12121509-Cells, Cultured,
pubmed-meshheading:12121509-Collagen,
pubmed-meshheading:12121509-Desmin,
pubmed-meshheading:12121509-Enzyme Induction,
pubmed-meshheading:12121509-Lipid Peroxidation,
pubmed-meshheading:12121509-Liver,
pubmed-meshheading:12121509-Male,
pubmed-meshheading:12121509-Malondialdehyde,
pubmed-meshheading:12121509-Rats,
pubmed-meshheading:12121509-Rats, Sprague-Dawley
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pubmed:year |
2002
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pubmed:articleTitle |
Aldehydic products of lipid peroxidation do not directly activate rat hepatic stellate cells.
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pubmed:affiliation |
Department of Medicine, University of Western Australia, Western Australian Institute of Medical Research, Perth, Australia.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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