Linked Life Data

12121307

Source:http://linkedlifedata.com/resource/pubmed/id/12121307

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2002-7-17
pubmed:abstractText
In EL mice, ictogenesis is established at age approximately 10 weeks, whereas epileptogenesis is induced through an experience of repetitive seizures during development. An "abnormal neural plasticity" has been suggested to be involved in these pathologic processes. It also is known that two isoforms of nitric oxide (NO) synthetase (nNOS and eNOS) are essential for the long-term potentiation (LTP), a plastic response of neurons. It appears, therefore, that these NO synthetases might play a major role in the establishment of abnormal neural plasticity. The purpose of the present study was to investigate ictogenesis and epileptogenesis by observing alterations of NO synthetases as well as immediate early gene (IEG) expressions and gamma-aminobutyric acid (GABA) distributions in the brain during development and with respect to seizure history.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0013-9580
pubmed:author
pubmed:issnType
Print
pubmed:volume
43 Suppl 5
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
130-5
pubmed:dateRevised
2005-11-17
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
Ictogenesis and epileptogenesis in EL mice.
pubmed:affiliation
Department of Neural Plasticity, Tokyo Institute of Psychiatry, 2-1-8 Kamikitazawa, Setagaya-ku, Tokyo 156-8585, Japan. murasima@prit.go.jp
pubmed:publicationType
Journal Article, Review