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rdf:type |
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lifeskim:mentions |
umls-concept:C0010068,
umls-concept:C0011155,
umls-concept:C0017431,
umls-concept:C0023821,
umls-concept:C0023822,
umls-concept:C0025266,
umls-concept:C0035647,
umls-concept:C0055538,
umls-concept:C0201950,
umls-concept:C0332281,
umls-concept:C0428466,
umls-concept:C0441994,
umls-concept:C0814861,
umls-concept:C1549054,
umls-concept:C2349179
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pubmed:issue |
7
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pubmed:dateCreated |
2002-7-15
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pubmed:abstractText |
We have previously reported that genetic variation at the cholesteryl ester transfer protein (CETP) TaqIB locus is correlated with plasma lipid levels and coronary heart disease (CHD) risk in the Framingham Offspring Study (FOS). In FOS, the B2 allele was associated with increased levels of high density lipoprotein (HDL) cholesterol (HDL-C), decreased CETP activity, and reduced CHD risk for men having the B2B2 genotype. The present study was undertaken to further define the relationship between this polymorphism and CHD risk at the population level.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Apolipoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/CETP protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol, HDL,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol Ester Transfer Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Gemfibrozil,
http://linkedlifedata.com/resource/pubmed/chemical/Genetic Markers,
http://linkedlifedata.com/resource/pubmed/chemical/Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Hypolipidemic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Lipids,
http://linkedlifedata.com/resource/pubmed/chemical/Lipoproteins, LDL
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1524-4636
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
22
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1148-54
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:12117730-Alleles,
pubmed-meshheading:12117730-Apolipoproteins,
pubmed-meshheading:12117730-Carrier Proteins,
pubmed-meshheading:12117730-Cholesterol, HDL,
pubmed-meshheading:12117730-Cholesterol Ester Transfer Proteins,
pubmed-meshheading:12117730-Coronary Disease,
pubmed-meshheading:12117730-Fasting,
pubmed-meshheading:12117730-Gemfibrozil,
pubmed-meshheading:12117730-Genetic Markers,
pubmed-meshheading:12117730-Genotype,
pubmed-meshheading:12117730-Glycoproteins,
pubmed-meshheading:12117730-Humans,
pubmed-meshheading:12117730-Hypolipidemic Agents,
pubmed-meshheading:12117730-Lipid Metabolism,
pubmed-meshheading:12117730-Lipid Metabolism, Inborn Errors,
pubmed-meshheading:12117730-Lipids,
pubmed-meshheading:12117730-Lipoproteins, LDL,
pubmed-meshheading:12117730-Male,
pubmed-meshheading:12117730-Middle Aged,
pubmed-meshheading:12117730-Molecular Weight,
pubmed-meshheading:12117730-Risk Factors,
pubmed-meshheading:12117730-United States,
pubmed-meshheading:12117730-United States Department of Veterans Affairs
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pubmed:year |
2002
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pubmed:articleTitle |
Cholesteryl ester transfer protein TaqI B2B2 genotype is associated with higher HDL cholesterol levels and lower risk of coronary heart disease end points in men with HDL deficiency: Veterans Affairs HDL Cholesterol Intervention Trial.
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pubmed:affiliation |
Lipid Metabolism Laboratory, JM-USDA-Human Nutrition Research Center on Aging at Tufts University and Department of Medicine, New England Medical Center, Boston, Mass 02111, USA. mbrousseau@hnrc.tufts.edu
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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