Source:http://linkedlifedata.com/resource/pubmed/id/12110132
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
2002-7-11
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| pubmed:abstractText |
Genetic susceptibility to rheumatoid arthritis (RA), a common autoimmune disease, is associated with certain HLA-DR4 alleles. Treatments are rarely curative and are often tied to major side effects. We describe the development of a humanized mouse model wherein new, less toxic, vaccine-like treatments for RA might be pretested. This model includes four separate transgenes: HLA-DR*0401 and human CD4 molecules, a RA-related human autoantigenic protein (HCgp-39), and a T-cell receptor (TCRalphabeta) transgene specific for an important HCgp-39 epitope, eliciting strong Th1 responses in the context of HLA-DR*0401.
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| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:issn |
1465-9905
|
| pubmed:author |
pubmed-author:BootsAnnemiekeA,
pubmed-author:CongJ WJW,
pubmed-author:CopeAndrewA,
pubmed-author:EmingRüdigerR,
pubmed-author:HallFrancesF,
pubmed-author:KanazawaSatoshiS,
pubmed-author:KobayashiKaytaK,
pubmed-author:MeijerinkJanJ,
pubmed-author:PeterlinMatijaM,
pubmed-author:RijndersAntoniusA,
pubmed-author:SønderstrupGreteG,
pubmed-author:SekineChiyokoC,
pubmed-author:ViscontiKevinK
|
| pubmed:issnType |
Print
|
| pubmed:volume |
4 Suppl 3
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
S133-40
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| pubmed:dateRevised |
2007-11-14
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| pubmed:meshHeading | |
| pubmed:year |
2002
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| pubmed:articleTitle |
Humanized mice as a model for rheumatoid arthritis.
|
| pubmed:affiliation |
Department of Microbiology and Immunology, Stanford University School of Medicine, California 94305, USA.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Review,
Research Support, Non-U.S. Gov't
|