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rdf:type |
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lifeskim:mentions |
umls-concept:C0009017,
umls-concept:C0017262,
umls-concept:C0034344,
umls-concept:C0058087,
umls-concept:C0185117,
umls-concept:C0334227,
umls-concept:C0449432,
umls-concept:C0591833,
umls-concept:C0740277,
umls-concept:C1179435,
umls-concept:C1524073,
umls-concept:C1548799,
umls-concept:C1705248,
umls-concept:C1880022,
umls-concept:C2911684
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pubmed:issue |
6
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pubmed:dateCreated |
2002-7-10
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pubmed:abstractText |
The association between the dihydrolipoamide acetyltransferase component (E2) of pyruvate dehydrogenase complex (PDC) and primary biliary cirrhosis (PBC) is clinically established. However, the detailed pathological function of the PDC-E2 gene is as yet unclear. In order to study the gene function in knockout and transgenic mouse models, we cloned and characterized the mouse PDC-E2 (mPDC-E2) gene. Because the expression level of PDC-E2 was elevated in PBC bile duct cells, we tried to construct a bile duct carcinoma cell line that overexpressed PDC-E2 as a PBC cell model.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0944-1174
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
37
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
449-54
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12108679-Acetyltransferases,
pubmed-meshheading:12108679-Amino Acid Sequence,
pubmed-meshheading:12108679-Animals,
pubmed-meshheading:12108679-Bile Duct Neoplasms,
pubmed-meshheading:12108679-Cloning, Molecular,
pubmed-meshheading:12108679-Dihydrolipoyllysine-Residue Acetyltransferase,
pubmed-meshheading:12108679-Humans,
pubmed-meshheading:12108679-Immunoblotting,
pubmed-meshheading:12108679-Mice,
pubmed-meshheading:12108679-Mice, Knockout,
pubmed-meshheading:12108679-Mice, Transgenic,
pubmed-meshheading:12108679-Mitochondrial Proteins,
pubmed-meshheading:12108679-Pyruvate Dehydrogenase Complex,
pubmed-meshheading:12108679-Rats,
pubmed-meshheading:12108679-Tumor Cells, Cultured
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pubmed:year |
2002
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pubmed:articleTitle |
Molecular cloning, and characterization and expression of dihydrolipoamide acetyltransferase component of murine pyruvate dehydrogenase complex in bile duct cancer cells.
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pubmed:affiliation |
Department of Gastroenterology and Cancer Gene Regulation, Kanazawa University Graduate School of Medical Sciences, Japan.
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pubmed:publicationType |
Journal Article
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